Study of the Serum Metabolomic Profile in Nonalcoholic Fatty Liver Disease: Research and Clinical Perspectives

Metabolites
Stefano GittoErica Villa

Abstract

In recent years, metabolomics has attracted great scientific attention. The metabolomics methodology might permit a view into transitional phases between healthy liver and nonalcoholic steatohepatitis. Metabolomics can help to analyze the metabolic alterations that play a main role in the progression of nonalcoholic steatohepatitis. Lipid, glucose, amino acid, and bile acid metabolism should be widely studied to understand the complex pathogenesis of nonalcoholic steatohepatitis. The discovery of new biomarkers would be important for diagnosis and staging of liver disease as well as for the assessment of efficacy of new drugs. Here, we review the metabolomics data regarding nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. We analyzed the main studies regarding the application of metabolomics methodology in the complex context of nonalcoholic steatohepatitis, trying to create a bridge from the basic to the clinical aspects.

References

Nov 7, 2007·Cell Metabolism·Jeffrey R Idle, Frank J Gonzalez
Jan 16, 2008·The Journal of Biological Chemistry·Yang ZhaoGuoqing Cao
Oct 25, 2008·Nature·Jeremy K Nicholson, John C Lindon
Dec 23, 2008·Journal of Lipid Research·Eoin FahyEdward A Dennis
Jun 9, 2009·Journal of Hepatology·Curtis K ArgoStephen H Caldwell
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Apr 29, 2010·Metabolism: Clinical and Experimental·Satish C KalhanMike Milburn
Oct 12, 2010·Mass Spectrometry Reviews·Maroun Bou KhalilDaniel Figeys
Oct 20, 2010·Best Practice & Research. Clinical Gastroenterology·Marcin KrawczykPiero Portincasa
Oct 5, 2011·The American Journal of Pathology·Ian N HinesArlin B Rogers
Feb 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naoki TanakaFrank J Gonzalez
Nov 20, 2012·Nucleic Acids Research·David S WishartAugustin Scalbert
May 30, 2013·Journal of Hepatology·Diren Beyoğlu, Jeffrey R Idle
Aug 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cynthia A MoylanAnna Mae Diehl
Nov 28, 2013·Clinics in Liver Disease·Francisco Barrera, Jacob George
Jan 13, 2015·Canadian Journal of Gastroenterology & Hepatology·Manuela G NeumanRadu M Nanau
Apr 14, 2015·Gastroenterology Research and Practice·S GittoP Andreone
Mar 31, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Federica Del ChiericoLorenza Putignani
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Jun 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·You ZhouHannele Yki-Järvinen
Sep 11, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Silvia SookoianCarlos J Pirola
Oct 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jari E KaikkonenOlli T Raitakari
Jan 14, 2017·Experimental & Molecular Medicine·Xiao-Lin LiuYi-Min Mao
Jan 31, 2017·Gastroenterology·Cristina AlonsoJosé M Mato
May 11, 2017·World Journal of Gastroenterology : WJG·Shu DongMing-Yu Sun
Oct 31, 2017·Expert Review of Gastroenterology & Hepatology·Stefano GittoPietro Andreone
Oct 31, 2017·The Journal of Clinical Investigation·John F O'SullivanRobert E Gerszten

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Citations

Feb 6, 2019·Metabolites·Lucia CarulliErica Villa
Dec 24, 2019·Journal of Animal Science and Biotechnology·Khuram ShahzadJuan J Loor
Jul 12, 2019·World Journal of Gastroenterology : WJG·José M MatoShelly C Lu
Nov 22, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Vanessa D de MelloJussi Pihlajamäki
Jan 15, 2021·Metabolism: Clinical and Experimental·Miriam LongoPaola Dongiovanni
Mar 30, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rachid JellaliEric Leclerc
May 18, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Zhanxuan E WuSally D Poppitt
Aug 10, 2018·Journal of Proteome Research·Joselyn AllenPamela A Hankey-Giblin
Aug 20, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Takako InoueYasuhito Tanaka

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Methods Mentioned

BETA
biopsy
nuclear magnetic resonance
metabolomics
gastric bypass

Software Mentioned

ClinLipMet

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