Study of the topographic distribution of ets-1 protein expression in invasive breast carcinomas in relation to tumor phenotype

Cancer Detection and Prevention
Eleni E MylonaLydia L Nakopoulou

Abstract

Ets-1 is a transcription factor, implicated in the regulation of expression of various genes'. The aim of the present study was to investigate the expression of ets-1 protein in invasive breast carcinomas and its correlation with classic clinicopathological parameters, patients' survival and various biological markers. Immunohistochemistry was performed in paraffin-embedded tissue specimens from 149 invasive breast carcinomas to detect the proteins ets-1, p53, topoisomerase IIalpha, matrix metalloproteinase-7 (MMP-7) and urokinase-type plasminogen activator receptor (uPAR). Results were subjected to univariate and multivariate statistic analysis. Ets-1 protein was detected in the 77.9% of the cases in the cytoplasm, in the 46.3% in the nucleus of the malignant cells, and in stromal fibroblasts as well. Cytoplasmic ets-1 was inversely correlated with nuclear and histologic grade of the tumor (p=0.004 and 0.033, respectively) and topoisomerase IIotaalpha (p=0.057), while nuclear ets-1 showed a positive association with p53 (p=0.002). Stromal ets-1 revealed a negative correlation with estrogen receptors (ER) (p=0.003) and a positive one with stromal uPAR and MMP-7 as well (p=0.048 and 0.066, respectively). The univariate statistic...Continue Reading

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Citations

Jun 30, 2011·Pigment Cell & Melanoma Research·Gianfranco MattiaAlessandra Carè
Sep 24, 2015·Seminars in Cancer Biology·Jürgen Dittmer
Sep 4, 2014·Genome Research·Hatice U OsmanbeyogluChristina S Leslie
Sep 16, 2008·Human Pathology·Yumei GuEnhua Wang
Apr 25, 2019·Journal of Cellular Biochemistry·Sheeraz Un NazirShowket Hussain

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