Abstract
Ets-1 is a transcription factor, implicated in the regulation of expression of various genes'. The aim of the present study was to investigate the expression of ets-1 protein in invasive breast carcinomas and its correlation with classic clinicopathological parameters, patients' survival and various biological markers. Immunohistochemistry was performed in paraffin-embedded tissue specimens from 149 invasive breast carcinomas to detect the proteins ets-1, p53, topoisomerase IIalpha, matrix metalloproteinase-7 (MMP-7) and urokinase-type plasminogen activator receptor (uPAR). Results were subjected to univariate and multivariate statistic analysis. Ets-1 protein was detected in the 77.9% of the cases in the cytoplasm, in the 46.3% in the nucleus of the malignant cells, and in stromal fibroblasts as well. Cytoplasmic ets-1 was inversely correlated with nuclear and histologic grade of the tumor (p=0.004 and 0.033, respectively) and topoisomerase IIotaalpha (p=0.057), while nuclear ets-1 showed a positive association with p53 (p=0.002). Stromal ets-1 revealed a negative correlation with estrogen receptors (ER) (p=0.003) and a positive one with stromal uPAR and MMP-7 as well (p=0.048 and 0.066, respectively). The univariate statistic...Continue Reading
References
Nov 15, 1992·Biochimica Et Biophysica Acta·D R EdwardsJ K Heath
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A McClellandR I Nicholson
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N K BhatT S Papas
Nov 24, 1983·Nature·D LeprinceD Stehelin
Sep 6, 1994·Annals of the New York Academy of Sciences·L M Matrisian
Apr 1, 1994·Endocrinology·M ItoS Yamashita
May 1, 1996·The Journal of Pathology·L L NakopoulouA Keramopoulos
Nov 21, 1998·Gut·I OzakiT Sakai
Mar 5, 1999·Breast Cancer Research and Treatment·R W StephensM Schmitt
Sep 1, 1999·Oncogene·U S KhooF C Ho
Dec 1, 2000·Cancer Letters·S TsutsumiE Mochiki
Feb 15, 2001·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·L NakopoulouP Davaris
Feb 15, 2001·Oncogene·M Trojanowska
May 1, 2001·The Journal of Pathology·P BehrensN Wernert
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T NakayamaI Sekine
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B DavidsonJ M Nesland
Dec 12, 2001·The Journal of Surgical Research·H SasakiY Fujii
May 25, 2002·Biochemical Society Transactions·Andrew D Sharrocks
Jun 13, 2002·Breast Cancer Research and Treatment·Jane M BarrettRichard G Tozer
Jun 20, 2002·Journal of Cancer Research and Clinical Oncology·S SoniR Ralhan
Dec 6, 2002·Oncogene·Paul N SpanC G J Sweep
Feb 1, 2003·Gene·Tsuneyuki Oikawa, Toshiyuki Yamada
Jan 6, 2004·Cellular and Molecular Life Sciences : CMLS·T RothhammerA-K Bosserhoff
Feb 28, 2004·Histopathology·T NakayamaI Sekine
Jul 14, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M C ErlandssonH Carlsten
Mar 1, 2012·International Journal of Oncology·Zaki Shaikhibrahim, Nicolas Wernert
Citations
Apr 21, 2009·Oncogene·C LaitemM Aumercier
Jun 30, 2011·Pigment Cell & Melanoma Research·Gianfranco MattiaAlessandra Carè
Sep 14, 2012·Breast Cancer Research : BCR·Christopher H SwitzerDavid A Wink
Nov 22, 2013·PloS One·Shufeng LiZi-Chun Hua
Sep 24, 2015·Seminars in Cancer Biology·Jürgen Dittmer
Aug 15, 2014·Cancer Cell·Gang LuWilliam G Kaelin
Sep 4, 2014·Genome Research·Hatice U OsmanbeyogluChristina S Leslie
Sep 16, 2008·Human Pathology·Yumei GuEnhua Wang
Apr 25, 2019·Journal of Cellular Biochemistry·Sheeraz Un NazirShowket Hussain
Jan 19, 2021·Breast Disease·Velibor Puzovic, Jasminka Jakic-Razumovic