Study of trinucleotide expansions and expression of androgen receptor in infertile men with abnormal spermogram referred to Royan institute

Andrologia
Parnaz Borjian BoroujeniAnahita Mohseni-Meybodi

Abstract

Androgen receptor (AR) mediates androgen activities such as the growth of accessory sex organs, and initiation and promotion of spermatogenesis. There are two trinucleotide polymorphisms (CAG and GGN repeats) in the first exon of AR gene that their association with infertility is still controversial. The variants of both polymorphic repeats were investigated by PCR-Sequencing in 220 infertile men (80 azoospermic, 60 oligospermic and 80 asthenospermic) and 80 healthy fertile controls. AR Expression level was quantified by RT-qPCR on 30 patients (20 patients with nonobstructive azoospermia (NOA) and 10 obstructive azoospermia patients as controls). Our results demonstrated that the medians of CAG and GGN repeats length in infertile group were significantly higher than fertile men (p < 0.05). AR expression results showed a significant increase in SCOS group compared to control (p < 0.05). Long stretches of tandem repeats of AR gene may negatively affect the function of the gene and consequently lead to male infertility. In patients with SCOS, AR expression increases because of the lack of germ cells. Therefore, with increasing AR expression, the probability of SCOS occurrence is also increased. It can be concluded that increasing ...Continue Reading

References

Dec 15, 1995·The Journal of Biological Chemistry·E LangleyE M Wilson
Mar 27, 2004·Molecular Human Reproduction·A FerlinC Foresta
Apr 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chawnshang ChangShuyuan Yeh
Apr 21, 2006·Asian Journal of Andrology·Hong-Gang LiCheng-Liang Xiong
Nov 2, 2006·Biological & Pharmaceutical Bulletin·Aifa TangZhiming Cai
Nov 9, 2006·Molecular Biology Reports·Zhendong YuZhiming Cai
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Meng-Yin TsaiChawnshang Chang
Jan 2, 2007·Molecular and Cellular Endocrinology·K B LundinY L Giwercman
Sep 25, 2007·Fertility and Sterility·Henrike WesterveldSjoerd Repping
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Badia BarakatKate L Loveland
Feb 26, 2009·Molecular Human Reproduction·Yongcui ZhouYaoting Gui
Nov 26, 2009·The International Journal of Biochemistry & Cell Biology·Nigel C BennettGlenda C Gobe
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William H Walker
Aug 26, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Laura O'Hara, Lee B Smith
May 10, 2016·Reproductive Biomedicine Online·Feifan XiaoXiaoli Yang

❮ Previous
Next ❯

Citations

Apr 30, 2019·Systems Biology in Reproductive Medicine·Vida FirouziAnahita Mohseni Meybodi
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoliang LiWenming Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.