Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky-Molodkina Strain Rats

Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
I B FedotovaI I Poletaeva

Abstract

The latency of tonic seizure in response to loud sound (in rats of the Krushinsky-Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times a day during 9 or 12 days). The recovery time from the tonic seizure was shorter after 12 days of injections in comparison to the 9-day injection period. At the same time, the intensity of tonic seizures provoked by loud sound did not change after chronic uridine injections. The lack of uridine anticonvulsive effect demonstrated in the audiogenic epilepsy model contradicts the anticonvulsant effects of uridine in experiments with other seizure models, in which the epileptic foci were localized in the forebrain structures.

References

Feb 15, 2003·FEBS Letters·Renato FerrantiAlicia J Kowaltowski
Apr 20, 2006·Epilepsy Research·Qian ZhaoGregory L Holmes
Sep 9, 2011·The New England Journal of Medicine·Patrick KwanMartin J Brodie
Aug 1, 2015·Epilepsy & Behavior : E&B·I I PoletaevaI B Fedotova
Jan 11, 2017·Journal of Bioenergetics and Biomembranes·Natalya I VenediktovaGalina D Mironova

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