Study on a 4-week recovery test of sweet bee venom after a 13-week, repeated, intramuscular dose toxicity test in sprague-dawley rats

Journal of Pharmacopuncture
Hyunmin KangKwangho Lee

Abstract

This study was performed to check for reversibility in the changes induced by a 13-week, repeated, dose toxicity test of Sweet Bee Venom (SBV) in Sprague-Dawley (SD) rats. Fifteen male and 15 female SD rats were treated with 0.28 mg/kg of SBV (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. (1) Hyperemia and movement disorder were observed in the 13-week, repeated, dose toxicity test, but these symptoms were not observed during the recovery period. (2) The rats in the high-dose group showed no significant changes in weight compared to the control group. (3) No significant differences in the ophthalmic parameters, urine analyses, complete blood cell counts (CBCs), and biochemistry were observed among the recovery groups. (4) No changes in organ weights were observed during the recovery period. (5) Histological examination of the thi...Continue Reading

References

Jan 15, 1976·European Journal of Biochemistry·J GauldieC A Vernon
Jul 28, 1972·Science·E Habermann

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Citations

Sep 22, 2015·Journal of Pharmacopuncture·Kwang-Ho LeeKiRok Kwon
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh

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Methods Mentioned

BETA
blood collection
gel filtration

Software Mentioned

SAS

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