PMID: 22568241May 10, 2012Paper

Study on andrographolide-induced apoptosis of Candida albicans biofilm dispersion cells

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Changzhong WangYan Wang

Abstract

To detect the effect of andrographolide on apoptosis of Candida albicans biofilm dispersion cells. The morphological changes of apoptotic C. albicans biofilm cells were observed by using Hoechst 33258 staining Fluorescence microscope; changes of mitochondrial membrane potential (MMP) of C. albicans biofilm cells were detected by rhodamine 123 staining flow cytometry; and reactive oxygen species (ROS) was detected by DHR staining flow cytometry. 1 000, 100 micromol x L(-1) of andrographolide could cause pyknosis and dense staining of C. albicans biofilm cells, 1 000, 100, 10 micromol x L(-1) of andrographolide could decrease MMP and increase ROS of C. albicans biofilm cells. Andrographolide of appropriate concentrations could induce apoptosis of dispersion cells of C. albicans biofilms.

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