Study on causes of fever in primary healthcare center uncovers pathogens of public health concern in Madagascar

PLoS Neglected Tropical Diseases
Julia GuillebaudJean-Michel Heraud

Abstract

The increasing use of malaria diagnostic tests reveals a growing proportion of patients with fever but no malaria. Clinicians and health care workers in low-income countries have few tests to diagnose causes of fever other than malaria although several diseases share common symptoms. We propose here to assess etiologies of fever in Madagascar to ultimately improve management of febrile cases. Consenting febrile outpatients aged 6 months and older were recruited in 21 selected sentinel sites throughout Madagascar from April 2014 to September 2015. Standard clinical examinations were performed, and blood and upper respiratory specimens were taken for rapid diagnostic tests and molecular assays for 36 pathogens of interest for Madagascar in terms of public health, regardless of clinical status. A total of 682 febrile patients were enrolled. We detected at least one pathogen in 40.5% (276/682) of patients and 6.2% (42/682) with co-infections. Among all tested patients, 26.5% (181/682) had at least one viral infection, 17.0% (116/682) had malaria and 1.0% (7/682) presented a bacterial or a mycobacterial infection. None or very few of the highly prevalent infectious agents in Eastern Africa and Asia were detected in this study, such ...Continue Reading

References

Nov 1, 1991·Research in Virology·J MorvanP Coulanges
Oct 1, 1993·Molecular and Biochemical Parasitology·G SnounouK N Brown
Apr 11, 2001·Emerging Infectious Diseases·L K Archibald, L B Reller
Jul 12, 2005·FEMS Microbiology Letters·Fabrice MerienGuy Baranton
Jan 23, 2010·BMC Public Health·Laurence RandrianasoloVincent Richard
May 29, 2010·Emerging Infectious Diseases·Soa Fy AndriamandimbyJean-Marc Reynes
Jul 20, 2010·The Lancet Infectious Diseases·Wendy Prudhomme O'MearaBrian Greenwood
Mar 11, 2011·PloS One·Norosoa Harline RazanajatovoJean-Michel Heraud
Apr 8, 2011·Tropical Medicine & International Health : TM & IH·John A CrumpGrace D Kinabo
May 6, 2011·Journal of Clinical Microbiology·Rogier R JansenJanke Schinkel
Aug 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Malavika PrabhuJohn A Crump
Nov 29, 2011·Asian Pacific Journal of Tropical Medicine·George Peter, Hegde Narasimha
Feb 4, 2012·The American Journal of Tropical Medicine and Hygiene·Matthew R KasperShannon D Putnam
May 17, 2012·Bulletin of the World Health Organization·Soatiana RajatonirinaVincent Richard
Sep 15, 2012·BMC Infectious Diseases·Marielle Karine Bouyou-AkotetMaryvonne Kombila
Jul 23, 2013·PLoS Neglected Tropical Diseases·John A CrumpJohn A Bartlett
Sep 11, 2013·Veterinary Research·Amélie DesvarsPascale Bourhy
Feb 28, 2014·The New England Journal of Medicine·Valérie D'AcremontBlaise Genton
Mar 19, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marietjie VenterRobert Swanepoel
Oct 17, 2014·Journal of Travel Medicine·Frédéric PagèsMarie-Christine Jaffar-Bandjee
Jan 20, 2015·Online Journal of Public Health Informatics·Soatiana RajatonirinaVincent Richard
Mar 12, 2015·The American Journal of Tropical Medicine and Hygiene·Wendy P O'MearaThomas L Holland
Apr 16, 2015·PloS One·Maherisoa RatsitorahinaUNKNOWN 2011 Surveillance Workshop group
Jul 8, 2015·The American Journal of Tropical Medicine and Hygiene·Mayfong MayxayPaul N Newton
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alfred PachFlorian Marks
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Florian MarksRaphaël Rakotozandrindrainy
May 15, 2016·The Journal of Infection·Terho Heikkinen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
chip
ELISA

Software Mentioned

StataIC
Access

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Transactions of the Royal Society of Tropical Medicine and Hygiene
J MorvanJ Roux
Journal of the American Veterinary Medical Association
Brian H BirdN James Maclachlan
The Southeast Asian Journal of Tropical Medicine and Public Health
Tri N Susilawati, William J H McBride
© 2022 Meta ULC. All rights reserved