Study on Coagulation Factor VIII and Fibrinogen Levels in Patients with Thyroid Disorders

Indian Journal of Endocrinology and Metabolism
Muhammed ThoyyibSanjay Pandit

Abstract

A kaleidoscope of coagulation disorders has been reported in patients with thyroid dysfunctions. Globally, these disorders involve both primary and secondary hemostasis and range from subclinical laboratory abnormalities to, more rarely, life-threatening hemorrhages or thrombotic events. While overt hypothyroidism appears to be associated with a bleeding tendency, hyperthyroidism emerged to have an increased risk of thrombotic events. As a controversy, subclinical hypothyroidism and mild hypothyroidism have been reported as prothrombotic state. The mechanisms involved in these observations are also not conformed. To study the levels of prothrombotic coagulation factor VIII and fibrinogen in patients with thyroid disorder at baseline and to correlate the change in these factors after attaining euthyroid state by treatment. This was a longitudinal interventional study. Forty patients were recruited based on the inclusion and exclusion criteria, and their coagulation profile (prothrombin time, aPTT, Factor VIII, and fibrinogen levels), routine hematological, and biochemical profile was done at baseline and 6 weeks after attaining euthyroid state. Hyperthyroidism and mild hypothyroidism were found to be hypercoagulable states and m...Continue Reading

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May 14, 2021·Frontiers in Endocrinology·Eleonore Fröhlich, Richard Wahl

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