Study on Dendrobium officinale O-Acetyl-glucomannan (Dendronan). 7. Improving Effects on Colonic Health of Mice

Journal of Agricultural and Food Chemistry
Guan-Ya ZhangGlyn O Phillips

Abstract

This research was aimed to study the effect of Dendrobium officinale polysaccharide (Dendronan) on colonic health. Mice were fed Dendronan at doses of 40, 80, and 160 mg/kg body weight for 0, 10, 20, and 30 days, respectively. Results showed that Dendronan, which has a special structure formed by mannose and glucose, rich in O-acetyl groups, exhibited improving effects on colonic and fecal parameters of Balb/c mice. After Dendronan feeding, the content of short-chain fatty acids (SCFAs), colon length and index, and fecal moisture were increased, whereas colonic pH was decreased and defecation time was shortened. All of these changes were significantly different between polysaccharide-treated groups and the control group (p < 0.05). These findings suggested that an adequate intake of Dendronan is beneficial to the process of fermentation and regulation of colonic microenvironment, thus playing a role in the maintenance of colonic health.

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Citations

Feb 2, 2017·Journal of Medicinal Food·DanDan LuoZiRen Su
Apr 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min XieMing-Yong Xie
Feb 16, 2017·Applied Microbiology and Biotechnology·Jaime A Teixeira da Silva, Tzi Bun Ng
Jun 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaiwei HuangChengfeng Wu
Apr 8, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hanxiao TangYongsheng Zhang
Jul 2, 2021·International Journal of Biological Macromolecules·Wen-Hua ChenLu-Ping Qin
Dec 27, 2018·Journal of the American Chemical Society·Robert LassfolkReko Leino
Apr 20, 2018·Journal of Agricultural and Food Chemistry·Jie-Lun HuMing-Yong Xie

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