PMID: 8597780Nov 24, 1995Paper

Study on didanosine concentrations in cerebrospinal fluid. Implications for the treatment and prevention of AIDS dementia complex

Pharmacy World & Science : PWS
D M BurgerJ H Beijnen

Abstract

It has been hypothesized that didanosine has a low efficacy in the prevention and treatment of patients with the dementia complex of acquired immunodeficiency syndrome (AIDS) because "... the drug has not been detected in the cerebrospinal fluid". We investigated didanosine concentrations in cerebrospinal fluid (CSF) and plasma of four patients with AIDS who were using didanosine chronically. Didanosine levels, 4 h after the last drug administration, averaged 0.16 (+/- 0.03) mumol/l in CSF and 0.70 (+/- 0.27) mumol/l in plasma. When compared with historical data from patients using zidovudine, didanosine concentrations in CSF appeared to be approximately half (on a molar base) those of zidovudine concentrations in the CSF. Whether this difference in CSF levels is the explanation for the presumed lower efficacy of didanosine in the prevention and treatment of AIDS dementia complex remains to be proven. However, it is clear from this study, in contrast with earlier suggestions, that didanosine is able to pass the blood-CSF barrier in human immunodeficiency virus-infected individuals.

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Citations

Dec 14, 2011·The Journal of Antimicrobial Chemotherapy·Aylin YilmazMagnus Gisslén
Jan 6, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brookie M BestUNKNOWN CHARTER Study Group
Oct 26, 2016·AIDS Research and Treatment·Jacinta Nwamaka NwoguBabafemi Taiwo
Aug 29, 2003·Journal of the International Association of Physicians in AIDS Care : JIAPAC·David A Cooper
Nov 14, 1998·AIDS·R H EntingP Portegies
Aug 3, 2002·CNS Drugs·Heather E WynnCourtney V Fletcher
Sep 10, 2014·Clinical Pharmacokinetics·Andrea CalcagnoStefano Bonora
Aug 24, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S KravcikD W Cameron
Aug 14, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sipho MdandaThavendran Govender
Apr 27, 2013·Molecular Pharmaceutics·Catia MarzoliniAnna Seelig

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