Study on drug release behaviour of CDHA/chitosan nanocomposites--effect of CDHA nanoparticles

Journal of Controlled Release : Official Journal of the Controlled Release Society
Tse-Ying LiuDean-Mo Liu

Abstract

To explore the effect of nanofiller-polymer interaction on the drug release behaviour from a monolithic membrane prepared by Ca-deficient hydroxyapatite (CDHA)/chitosan nanocomposite, release kinetics was investigated in terms of different synthetic processes, i.e. in situ and ex situ routes, and various amounts of CDHA. It was found that a higher value of diffusion exponent (n) was obtained for the membranes in situ synthesized compared with those ex situ prepared. In addition, the n value of the membranes in situ synthesized increased with increasing CDHA amount, which remained in the range below 10wt.%. However, as CDHA content exceeded 30%, the n value remained constant. It indicates that the drug diffusion mechanism is altered by the CDHA-chitosan interaction which is strongly influenced by both the synthesis process and the concentration of the CDHA nanofiller in the membrane. On the other hand, a lower permeability (P) value of the membranes was observed for those prepared via the in situ process. Furthermore, P value decreased and increased with increasing CDHA amount in the range below and above 10wt.%, respectively. It demonstrates that CDHA nanofillers act either diffusion barrier or diffusion enhancer for the CDHA/c...Continue Reading

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Citations

Feb 2, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ting-Yu LiuSan-Yuan Chen
Jul 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shang-Hsiu HuSan-Yuan Chen
Dec 17, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shu-Hua TengHyoun-Ee Kim
Jul 23, 2013·Journal of Biomedical Materials Research. Part a·M DessìL Ambrosio
Dec 20, 2008·Journal of Biomedical Materials Research. Part a·Yufeng TangXianwen Hu
Sep 17, 2013·Journal of Biomedical Materials Research. Part a·Kamal K GuptaPralay Maiti
Aug 1, 2015·Therapeutic Delivery·Hyder Aliyar, Gerald Schalau
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Vahid Asadian-ArdakaniSaeed Saber-Samandari
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Jucélia L DantasSuédina Maria de L Silva

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