PMID: 11930691Apr 5, 2002Paper

Study on endothelial cell injury in women with pregnancy induced hypertension

Zhonghua fu chan ke za zhi
W ZhaoL Wang

Abstract

To investigate the mechanisms of endothelial cell injury in women with pregnancy induced hypertension (PIH). Human umbilical endothelial cells were cultured in the serum from 10 women with severe PIH and 10 normal pregnant women, and co-cultured with neutrophils or not for 48 hrs. The morphology and cell cycles were studied. Without neutrophils, no apoptotic cells were observed, while neutrophils were added, apoptotic cells were obviously detected. The percentage of apoptotic cells in PIH was more than that in non-PIH. The percentage of cells in G2/M phase decreased in all the groups, but there were no significant differences among them. Endothelial cells were injured indirectly in PIH patients. Activated neutrophils induced apoptosis might be one of the answers.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis