Study on expression of laminin in patients with intractable epilepsy

The International Journal of Neuroscience
Yuan WuXue-Feng Wang

Abstract

In this study, we examined differences in serum laminin expression in patients with intractable epilepsy. Our results suggest that elevated laminin may contribute to the pathogenesis of intractable epilepsy. ELISA and western blots were used to measure laminin in the serum of 30 intractable epilepsy patients, 46 nonintractable epilepsy patients, and 20 normal subjects. By ELISA, serum laminin levels were greater in intractable epilepsy patients (177.396 +/- 30.602) and nonintractable epilepsy patients (121.915 +/- 35.215) than in normal control subjects (67.474 +/- 7.197); laminin was significantly greater in the intractable epilepsy group than in the nonintractable epilepsy group. In western blots, the optical density ratio of laminin to ss-actin was 0.871 +/- 0.032 for the intractable epilepsy group, 0.686 +/- 0.017 for the nonintractable epilepsy group, and 0.385 +/- 0.024 for the normal control group. The optical density ratios of the intractable and nonintractable epilepsy groups were higher than those for the normal control group, and the intractable epilepsy group was even greater than the nonintractable epilepsy group. Thus, laminin is significantly increased in epilepsy patients, and this increase is more profound in i...Continue Reading

References

Oct 3, 2003·Trends in Neurosciences·Maiken NedergaardSteven A Goldman
May 10, 2005·Nature Neuroscience·Stephen G Turney, Paul C Bridgman
Aug 12, 2008·Neuroscience Letters·Yuan WuJin-ou Zheng

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Citations

Sep 4, 2013·Journal of the American Medical Informatics Association : JAMIA·Jae-Yoon JungDennis P Wall
Aug 28, 2019·The Cochrane Database of Systematic Reviews·Rebecca BresnahanAnthony G Marson

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