PMID: 9642340Jan 1, 1996Paper

Study on expression of nm23-H1 gene in laryngeal cancer tissues

Zhonghua er bi yan hou ke za zhi
Q WangL Sun

Abstract

The nm23 gene is a metastasis suppressor gene. There are now two known isotypes of human nm23, namely nm23-H1 and nm23-H2. Several investigators have reported that reduced expression of nm23-H1 is associated with metastasis or disease progression in some of the tumor cases. In this study, the expression of nm23-H1 mRNA in the human laryngeal squamous cell carcinoma was investigated by Northern blot analysis. The levels of nm23-H1 mRNA were higher in cancers (n = 31) than in the adjacent normal tissues (n = 7), but the difference was not significant (P > 0.05). There was a significant decrease of nm23-H1 mRNA levels in tumors with lymph node metastasis (n = 11) as compared with those without (n = 20) (P < 0.01). Cancer tissues in clinical stages III-IV. (n = 23) also exhibited lower levels of nm23-H1 mRNA expression than those in stages I-II (n = 8) (P < 0.05). These results suggest that the nm23-H1 gene may play a role in the suppression of lymph node metastasis or disease progression in laryngeal cancer.

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
J LiS Yin
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
L LiuZ Sun
© 2022 Meta ULC. All rights reserved