PMID: 11206555Feb 24, 2001

Study on fluorescent property of degrading products of piperacillin and its analytical application

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
B TangH Y Wang

Abstract

The fluorimetric property of the degrading products of piperacillin has been studied in detail. The studies on degrading pH, degrading time, detection alkalinity and other corresponding analytical parameters of acid degradation have been made. Then fluorometry of piperacillin was established by producing its stable fluorescent products. The detection limit for acid degradation analytical method is 2.34 ng/ml, the linear range is 7.80-4.0 x 10(2) ppb. The analytical sensitivity, precision and stability of degrading products of acid degradation are satisfactory, which has been used for the determination of the trace piperacillin in human serum and urine with satisfactory results.

References

Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·V GautierG Vinçon
Mar 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·W CullmannM Edelmann
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaM Tomassetti

Related Concepts

Hydrogen-Ion Concentration
Penicillin
Piperacillin-ratiopharm
Fluorescence Spectroscopy

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