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Study on forced degradation behaviour of dofetilide by LC-PDA and Q-TOF/MS/MS: Mechanistic explanations of hydrolytic, oxidative and photocatalytic rearrangement of degradation products

Journal of Pharmaceutical and Biomedical Analysis

Nov 30, 2019

Bhargavi ThalluriM V N Kumar Talluri

Abstract

A solution and solid state forced decomposition study was carried on dofetilide under diverse stress conditions of hydrolysis, oxidation, photolysis and thermal as per International Council for Harmonisation guidelines (ICH) Q1A(R2) to understand its degradation behaviour. A total of ei...read more

Mentioned in this Paper

Study
Patterns
TOF MS (Time of Flight Mass Spectrometry)
RFX5 gene
Oxides
Oxidation
Pharmacologic Substance
High Pressure Liquid Chromatography Procedure
Ammonium acetate
Structure
1
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Study on forced degradation behaviour of dofetilide by LC-PDA and Q-TOF/MS/MS: Mechanistic explanations of hydrolytic, oxidative and photocatalytic rearrangement of degradation products

Journal of Pharmaceutical and Biomedical Analysis

Nov 30, 2019

Bhargavi ThalluriM V N Kumar Talluri

PMID: 31780282

DOI: 10.1016/j.jpba.2019.112985

Abstract

A solution and solid state forced decomposition study was carried on dofetilide under diverse stress conditions of hydrolysis, oxidation, photolysis and thermal as per International Council for Harmonisation guidelines (ICH) Q1A(R2) to understand its degradation behaviour. A total of ei...read more

Mentioned in this Paper

Study
Patterns
TOF MS (Time of Flight Mass Spectrometry)
RFX5 gene
Oxides
Oxidation
Pharmacologic Substance
High Pressure Liquid Chromatography Procedure
Ammonium acetate
Structure
1

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