Study on hydrophilicity and degradability of chitosan/polylactide-co-polycaprolactone nanofibre blend electrospun membrane

Carbohydrate Polymers
R DoratiI Genta

Abstract

Electrospinning is an interesting technique to produce polymer membranes made of entangled nanofibres. The technique is raising interest in pharmaceutical and biomedical areas. Either electrospun membranes are studied for tissue regeneration purposes, or incorporation of nanoparticles in electrospun membranes can be an opportunity to control the delivery of drug or to obtain dual drug delivery system. In this work suspensions of hydrochloride chitosan salt in copolymer polylactide-co-polycaprolactone (PLA-PCL) solution were electrospun in order to assess an advanced study for developing polymer nanofibre blend membrane loaded with chitosan polymer. The aim of the work was to investigate the properties and stability of chitosan/PLA-PCL electrospun membranes considering their application for tissue regeneration and drug delivery. The electrospun membranes were characterized for their physico-chemical (FT-IR) morphology (SEM) and in vitro biological properties (cytocompatibility and cells engraftment). Results show that homogeneous electrospun PLA-PCL/chitosan blend nanofibres in the range size 800 nm were obtained. Chitosan was loaded inside the nanofibres up to 27.2% (w/w) without modifying nanofibre shape, and only 6% of the lo...Continue Reading

Citations

Mar 8, 2020·International Journal of Molecular Sciences·Silvia PisaniBice Conti
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Cen ZhangHui Zhang
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Trinh Thi-Phuong HoThi-Hiep Nguyen
Feb 5, 2021·International Journal of Pharmaceutics·Rossella DoratiBice Conti
Oct 9, 2019·Carbohydrate Polymers·Qasim ZiaJiashen Li

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