Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D

Diabetology & Metabolic Syndrome
Lucy Baldeón RojasPieter J M Leenen

Abstract

Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with type 2 diabetes (T2D). In contrast, we found that the circulating monocytes lacked up-regulation of classical inflammatory genes (IL-1B, IL-6, and TNF) and there was even significant down-regulation of PTGS2. Notably, genes and a microRNA involved in adhesion, cell differentiation and morphology (CD9, DHRS3, PTPN7 and miR-34c-5p) were up-regulated in the T2D monocytes, suggesting a role of the anti-inflammatory cells in adhesion, vascular repair and invasion. To determine the gene expression of the vascular repair factor HGF in the circulating monocytes of patients with T2D and to investigate the relationship between HGF and the expression of the other previously tested monocyte genes and the contribution to the raised serum level of HGF. In addition, we tested the level of 6 microRNAs, which were previously found abnormal in the circulating monocytes, in the serum of the patients. A gene and microRNA expression study in monocytes and serum of 64 Ecuadorian patients with T2D (37-85 years) and 44 non-diabetic controls (32-87 years). The gene expression of HGF was significa...Continue Reading

References

Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SchirmacherC E Rogler
Jul 1, 1993·The American Journal of Physiology·E JennischeG L Matejka
Sep 11, 1998·Science·M R Sierra-HonigmannJ R Flores-Riveros
Dec 18, 2003·The Journal of Clinical Investigation·Kathryn E Wellen, Gokhan S Hotamisligil
Mar 28, 2006·Diabetes Research and Clinical Practice·Wan Sub ShimBong Soo Cha
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·Lauren N BellRobert V Considine
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Dec 13, 2006·Bipolar Disorders·Esther M KnijffHemmo A Drexhage
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Feb 9, 2007·European Journal of Endocrinology·G D NorataA L Catapano
Sep 6, 2007·The Journal of Clinical Investigation·Yihai Cao
May 14, 2008·Current Pharmaceutical Design·Leonie K Heilbronn, Lesley V Campbell
Jul 1, 2008·Biochemical and Biophysical Research Communications·Kristen D Singleton, Paul E Wischmeyer
Jul 5, 2008·Diabetes·Roos C PadmosUNKNOWN LADA Consortium
Oct 7, 2008·Journal of Diabetes and Its Complications·Małgorzata GackaAnna Sadakierska-Chudy
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G S Hotamisligil
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Bernardo Léo WajchenbergMaria Elizabeth Rossi da Silva
Aug 19, 2009·Molecular and Cellular Endocrinology·V Christiaens, H R Lijnen
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Jan 21, 2011·Molecular and Cellular Biochemistry·M BalasubramanyamV Mohan
May 28, 2011·Trends in Immunology·Elise DalmasMichèle Guerre-Millo
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Filip K Swirski
Feb 4, 2012·Circulation Research·Anna Zampetaki, Manuel Mayr
Jun 12, 2012·International Immunopharmacology·Yingying SuFan Li
Dec 25, 2012·Atherosclerosis·Giuseppe Danilo NorataCarlos Fernández-Hernando
Apr 5, 2013·PloS One·Takeshi ChiyomaruRajvir Dahiya
Sep 21, 2013·Reviews in Endocrine & Metabolic Disorders·H L KammounM A Febbraio
Nov 20, 2013·Trends in Immunology·Leen CatrysseGeert van Loo
Dec 26, 2013·Journal of Neuroimmunology·Nicolas MolnarfiPatrice H Lalive
Sep 9, 2015·JAMA : the Journal of the American Medical Association·Andy MenkeCatherine C Cowie

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Citations

Jan 31, 2016·Gene·Durairaj SekarKrishnan Ramalingam
Oct 27, 2017·Annals of Clinical Biochemistry·Xianjuan ShenShaoqing Ju
Dec 12, 2018·Molecular Medicine Reports·Yingcheng WuJiancheng Dong
Mar 8, 2017·International Journal of Molecular Sciences·Yuqing HeKai Wang
Dec 22, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gara Arteaga-HenriquezHemmo A Drexhage
Jun 16, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fuyan WangYisheng Zhang

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Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

miRecords
RNA22
SDS
Ingenuity Systems
MirTarget2
Data Assist
MAGPIX
TargetScanS
DIANA
NBmiRTar

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