Study on pancreatic lymphatics in nonobese diabetic mouse with prevention of insulitis and diabetes by adjuvant immunotherapy

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Peng QuSeiji Kato

Abstract

The present study has investigated the relationship between pancreatic lymphatics, infiltrating cells, and insulitic development after a single injection of complete Freund's adjuvant (CFA) given at an early age in the nonobese diabetic (NOD) mice. No CFA-treated NOD mice developed hyperglycemia, whereas most CFA-untreated mice died of diabetes at the age of 20-30 weeks. In untreated NOD mice, the increased infiltration of dendritic cells (DCs) and T-lymphocytes into the pancreatic islets appeared to be consistent with the increased expression of the secondary lymphoid chemokine (CCL21) and CD(31) by the endothelial cell lining of inter- and intralobular lymphatics. As the infiltration became severe, the reaction products of CCL21 and CD(31) were distributed in the nucleus and cytoplasm of lymphatic endothelial cells (LECs), through which DCs and T-lymphocytes migrated frequently. Administration of CFA reduced the number of infiltrating DCs and T-lymphocytes, but did not affect macrophage infiltration. The peri-insulitis occurred in numerous islets of CFA-treated NOD mice without the appearance of the intraislet infiltration and islet-associated lymphoid-like tissues. Furthermore, significant suppression of CCL21 and CD(31) was...Continue Reading

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Citations

Jul 1, 2006·Lymphatic Research and Biology·Rui-Cheng Ji
Sep 14, 2007·Scandinavian Journal of Immunology·B BieleckiA Glabinski
Apr 13, 2010·Expert Review of Clinical Immunology·Jamil AzziReza Abdi
Mar 5, 2014·The Journal of Clinical Investigation·Nancy H Ruddle
Feb 23, 2010·Nature Reviews. Endocrinology·Nikolai Petrovsky

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