PMID: 24331966Dec 18, 2013Paper

Study on patients with Creutzfeldt-Jakob disease in Shanghai, 2006-2012

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Pu HuangJian Chen

Abstract

To describe the epidemiological characteristics of patients with Creutzfeldt-Jakob disease (CJD) in Shanghai from 2006 to 2012. Clinical and epidemiological information on CJD patients from Shanghai CJD Surveillance Network was analyzed. Cerebral spinal fluid (CSF)and blood specimens from patients were collected and used for detecting the 14-3-3 protein, and polymorphism of 129 amino acid and mutation of PRNP genes. Data was processed by EpiData(V3.0)and analyzed by SPSS(V17.0). In totally, one definite CJD patient together with 56 probable and 17 possible sporadic CJD patients were identified. One E200K genetic CJD case was diagnosed and another one was clinically diagnosed. No period- or geographic-related events were observed for these cases, but the houses of the two genetic CJD cases were close to each other. The mean age of onset of the probable CJD patients was 62 years old which was significantly older than that of those possible CJD patients. Most of the CJD patients identified in Shanghai were sporadic and the number was stable from 2006 to 2012. The mean age of onset of those probable CJD patients was older than that of the possible CJD patients.

Related Concepts

Related Feeds

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Chan TianXiao-Ping Dong
Nederlands tijdschrift voor geneeskunde
F B van der WurffA Hijdra
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Chen GaoXiao-Ping Dong
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Jia-Yu HuYu-Chao Wang
© 2021 Meta ULC. All rights reserved