Study on poly(L-lactide-co-trimethylene carbonate): synthesis and cell compatibility of electrospun film

Biomedical Materials
Li-Jie JiZhong-Wei Gu

Abstract

The biomedical applications of poly(l-lactide) (PLLA) were limited by its high crystallinity. In this paper, the copolymerization of trimethylene carbonate (TMC) and l-lactide (LLA) was carried out to improve the flexibility of PLLA. The effects of feeding dose, reaction temperature and polymerization time were investigated, and the copolymers were characterized with (1)H nuclear magnetic resonance, Fourier transform infrared reflection, gel permeation chromatography differential scanning calorimetry, thermogravimetric analysis and x-ray diffraction. The copolymers were electrospun to form porous films to study their cell compatibility. The results showed that the composition of the copolymer was nearly the same as that in the feeding dose, and the molecular weight of the copolymer decreased with increasing TMC content. The decrease in the reaction temperature and polymerization time would increase the molecular weight, but the composition deviates from the feeding dose. NIH/3T3 mouse fibroblast cells were cultured on the electrospun films. The morphology and proliferation of the cells were studied. The results implied that the cell compatibility of poly(l-lactide-co-trimethylene carbonate) copolymer was much better than that o...Continue Reading

References

Jan 11, 2005·Biomacromolecules·Doris PospiechOliver Petermann
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Masafumi NakagawaJunzo Takahashi
Apr 22, 2006·Journal of Biomedical Materials Research. Part a·Shanta Raj BhattaraiHak Yong Kim
Jun 13, 2008·Angewandte Chemie·Erik WischerhoffJean-François Lutz
Aug 12, 2009·Journal of Bioscience and Bioengineering·Hiroshi YanagidaKazuo Takakuda

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Citations

Aug 15, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D I BraghirolliP Pranke
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jorja CorkLisbeth Grøndahl
Jul 23, 2016·Journal of Applied Biomaterials & Functional Materials·Michele M NavaRiccardo Pietrabissa

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