PMID: 9181177Jan 1, 1996Paper

Study on possible increase in twinning rate at a small village in south Brazil

Acta geneticae medicae et gemellologiae
U MatteR Giugliani

Abstract

A high frequency of twin births has been observed in Linha São Pedro, a small settlement which belongs to the city of Cãndido Godói, located 524 km Northwest from Porto Alegre, Rio Grande do Sul, Brazil, in an ethnically homogeneous population of German descent restricted to a small geographic region. From 1990 to 1994, the proportion of twin births in Linha São Pedro was 10%, significantly higher than the 1.8% rate for the state of Rio Grande do Sul as a whole. Genealogical analysis showed a high recurrence of multiple births within families, as well as a high level of inbreeding in the community. Zygosity data indicated that 9 of the 17 pairs of twins studied (53%) were dizygotic. No external environmental factors were detected that could be influencing the appearance of this characteristic. This preliminary investigation confirmed the presumed existence of a high twinning rate in the community. The high familial recurrence and the high inbreeding rate suggests the presence of genetic twinning factors. Complementary studies of twins that have yet to be evaluated and the search for additional risk factors, as well as linkage studies, should contribute to a further understanding of the biological factors related to twin births ...Continue Reading

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Citations

Dec 2, 2000·Nature Genetics·A BusjahnB Müller-Myhsok
Dec 15, 2005·American Journal of Physical Anthropology·John J ElyD Rick Lee
Jun 21, 2011·PloS One·Alice Tagliani-RibeiroLavinia Schuler-Faccini
Feb 26, 2011·The Journal of Obstetrics and Gynaecology Research·P Sahab Khan, K P Skandhan
Feb 2, 2013·Annals of Human Genetics·Marcelo Zagonel De OliveiraVirginia Ramallo
Mar 8, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Augusto César Cardoso-Dos-SantosLavínia Schuler-Faccini
Apr 16, 2019·Genetics and Molecular Biology·Roberto GiuglianiFrancyne Kubaski
Jun 28, 2012·Human Reproduction·A Tagliani-RibeiroU Matte

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