Study on Realgar inducing apoptosis in T lymphocytic cell line CEM

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Chen ZhangAi-Xia Guo

Abstract

To study the Realgar induced T lymphocytic leukemia cell line CEM apoptosis in vitro. CEM cells were incubated with Realgar. Cell proliferation inhibition was determined by MTT. Cell cycle, apoptosis, Apo2.7 and Fas were measured by cytometer. Realgar inhibited the proliferation of CEM cell line. The cells treated with Realgar showed a Sub-G(0)/G(1) apoptotic peak in DNA distribution histogram, increment of Apo2.7 protein expression, and arrested cells in G(2)/M phase, but ineffectiveness on Fas expression. The Realgar can induce CEM cell apoptosis in vitro.

Citations

Mar 12, 2013·Journal of Deaf Studies and Deaf Education·Ka Yan CheungBradley McPherson
Jul 31, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ya-ling Fu, Tao Chen
Sep 22, 2005·Journal of Ethnopharmacology·Han-Qing YeHui-Bi Xu

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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