Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma.

World Journal of Gastroenterology : WJG
Shang-Wen DongYuan-Guo Wang

Abstract

To investigate the promoter region methylation status of retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) in the human esophageal squamous cell carcinoma (ESCC) cell lines and tissues and verify the relationship between methylation of RIZ1 and oncogenesis, tumor progression and metastasis etc of ESCC. Methylation-specific polymerase chain reaction (MSP) was used to investigate the promoter region methylation status of RIZ1 in 6 ESCC cell lines. One cell line where RIZ1 promoter region methylation was detected was selected for the next study, where the cell line was treated with 5-aza-CdR. Real-time polymerase chain reaction was used to investigate its influence on the transcription of RIZ1. Experiments using frozen pathological specimens from 47 ESCC patients were performed using the same MSP methodology. Promoter methylation of RIZ1 gene was detected in TE13, CaEs17 and EC109 cell lines and the cell line TE13 was chosen for further study. The expression of RIZ1 mRNA in TE-13 was up-regulated after treatment with 5-aza-CdR. The rate of methylation in carcinomas tissues was significantly higher than those in matched neighboring normal and distal ending normal tissue, and the deviation of data was statistically signif...Continue Reading

References

Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·R MontesanoP Hainaut
Jan 10, 1998·Trends in Genetics : TIG·S U KassA P Wolffe
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·B S ChenM Wu
Mar 22, 2001·British Journal of Cancer·W FangS Huang
Oct 10, 2003·Oncogene·Yutaka TokumaruDavid Sidransky
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Yasuhiro OshimoWataru Yasui
May 13, 2004·Onkologie·R MetzgerA H Hölscher
Dec 17, 2005·Experimental Cell Research·Patrizia GazzerroGiovanni Alfredo Puca

❮ Previous
Next ❯

Citations

Oct 12, 2013·World Journal of Gastroenterology : WJG·Shang-Wen DongPeng Zhang
May 1, 2012·Pathology, Research and Practice·A PoehlmannA Roessner
Oct 21, 2016·Cellular and Molecular Neurobiology·Chenran ZhangJie Ma
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Peng GeJian Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.