PMID: 16792897Jun 24, 2006

Study on the association between transforming growth factor alpha gene TaqI variant and cleft lip with or without cleft palate

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JiangHui ZhuZhu Li

Abstract

To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population. TGFalpha TaqI variant was detected using polymerase chain reaction-restriction fragment length polymorphism for DNA samples of the 149 triads with nsCL/P affected child. We performed the Transmission/disequilibrium test and the family-based association study (FBAT) to identify the associations between this variant and risk of nsCL/P. Significant distortion of C2 allele at TGFalpha TaqI locus in nsCL/P groups (P > 0.05) was not found. In the family-based association test, C2 allele and offspring C2C1 genotype was not found to be significantly associated with an increase risk of nsCL/P (P > 0.05). Our findings did not suggest an association between offspring TGFalpha TaqI variant and the increased risk of nsCL/P in Chinese population.

Related Concepts

Cleft Lip
Cleft Palate, Isolated
Restriction Fragment Length Polymorphism
Nested Polymerase Chain Reaction
Transforming Growth Factor alpha
Genetic Predisposition to Disease

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