PMID: 16792897Jun 24, 2006

Study on the association between transforming growth factor alpha gene TaqI variant and cleft lip with or without cleft palate

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JiangHui ZhuZhu Li


To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population. TGFalpha TaqI variant was detected using polymerase chain reaction-restriction fragment length polymorphism for DNA samples of the 149 triads with nsCL/P affected child. We performed the Transmission/disequilibrium test and the family-based association study (FBAT) to identify the associations between this variant and risk of nsCL/P. Significant distortion of C2 allele at TGFalpha TaqI locus in nsCL/P groups (P > 0.05) was not found. In the family-based association test, C2 allele and offspring C2C1 genotype was not found to be significantly associated with an increase risk of nsCL/P (P > 0.05). Our findings did not suggest an association between offspring TGFalpha TaqI variant and the increased risk of nsCL/P in Chinese population.

Related Concepts

Cleft Lip
Cleft Palate, Isolated
Restriction Fragment Length Polymorphism
Nested Polymerase Chain Reaction
Transforming Growth Factor alpha
Genetic Predisposition to Disease

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
Wen-Guang ZhangJie Liang
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Ying HuXin-hua Zhang
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Jin-Zhen GuoYong Li
© 2021 Meta ULC. All rights reserved