Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma.

Gut Microbes
Alexander KrüttgenChristoph Roderburg

Abstract

Helicobacter species are important pathogens and previous studies in mice suggested a link between colonization by Helicobacter hepaticus (H. hepaticus) and hepatocellular carcinoma (HCC). This study aimed at corroborating this potential link in human patients. We used a sensitive and specific Helicobacter ssp PCR assay to screen stool samples from a collective of patients with viral-induced HCC (hepatitis B or hepatitis C) and a control group for presence of Helicobacter ssp DNA. Although retrieving DNA of H. pylori and H. canadensis from stool samples of non-HCC patients, we found no evidence indicating the presence of H. hepaticus in HCC-patients with chronic hepatitis B or hepatitis C. Interestingly we found H. canadensis in a stool sample of a patient presenting with diarrhea. Taken together, our data argue against a pathogenic role of H. hepaticus in viral-induced HCC. Yet, our results do not exclude a role of H. hepaticus in those HCC cases caused by other carcinogens, such as aflatoxin. Moreover, we speculate that H. canadensis might be a novel gastrointestinal pathogen.

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Citations

May 2, 2014·World Journal of Gastroenterology : WJG·Cong HeNong-Hua Lu
Sep 18, 2013·Helicobacter·Claire Roubaud BaudronAntonio Gasbarrini
Mar 15, 2015·Gastroenterología y hepatología·José F García-MazcorroJosé L Tamayo
Jan 10, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ting-Chin David ShenVinod K Rustgi
May 12, 2018·Nature Reviews. Gastroenterology & Hepatology·Anupriya TripathiRob Knight
Apr 10, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Concetta PanebiancoValerio Pazienza
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Aug 14, 2019·Medicina·Aleksejs DerovsAngelika Krumina
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Katherine Jp SchwengerJohane P Allard
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao

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