Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method

Medicine
Wei LiuYuan-Hao Wu

Abstract

Dermatomyositis is a common connective tissue disease. The occurrence and development of dermatomyositis is a result of multiple factors, but its exact pathogenesis has not been fully elucidated. Here, we used biological information method to explore and predict the major disease related genes of dermatomyositis and to find the underlying pathogenic molecular mechanism.The gene expression data of GDS1956, GDS2153, GDS2855, and GDS3417 including 94 specimens, 66 cases of dermatomyositis specimens and 28 cases of normal specimens, were obtained from the Gene Expression Omnibus database. The 4 microarray gene data groups were combined to get differentially expressed genes (DEGs). The gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichments of DEGs were operated by the database for annotation, visualization and integrated discovery and KEGG orthology based annotation system databases, separately. The protein-protein interaction networks of the DEGs were built from the STRING website. A total of 4097 DEGs were extracted from the 4 Gene Expression Omnibus datasets, of which 2213 genes were upregulated, and 1884 genes were downregulated. Gene ontology analysis indicated that the biological functions of DEGs...Continue Reading

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Related Concepts

Double-Stranded RNA Binding Domain
Dermatomyositis, Childhood Type
Homo sapiens
Interferon Type I
Plasma Protein Binding Capacity
Signal Transduction Pathways
Receptor Down-Regulation
Receptor Up-Regulation
Incidence
Computational Molecular Biology

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