Study on the dissolution improvement of albendazole using reconstitutable dry nanosuspension formulation

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Viktor FülöpIstván Antal

Abstract

The aim of the study was to improve the solubility and dissolution rate of the poorly water soluble drug albendazole via surfactant assisted media milling process. Preparation of a nanosuspension and then post-processing with a solidification technique applied to improve the applicability of nanosuspension in a solid dosage forms carrier. The dry nanosuspension was obtained using microcrystalline cellulose as solid carrier after tray drying at 40 °C. Both reconstitution from the solid carrier and dissolution profile studies were investigated in biorelevant Artificial Rumen Fluid (ARF) at pH = 6.50 and dissolution media at pH = 1.20 and pH = 6.80. Reconstitution studies have demonstrated that the mean hydrodynamic diameter values of albendazole crystals released from the dry suspension were nanosized (intensity weighted hydrodynamic diameter values: 200.40 ± 2.318 nm in ARF at pH = 6.50, 197.17 ± 0.208 nm in dissolution medium at pH = 6.80). Thermodynamic solubility studies have indicated a 2.98 times increase in water solubility (144.41 ± 0.09 μg/ml milled, 48.38 ± 0.01 μg/ml unmilled, 8.21 ± 0.02 μg/ml albendazole powder) in ARF at pH = 6.50, and 2.33 times in dissolution medium at pH = 6.8: (146.27 ± 0.28 μg/ml milled, 62.71 ...Continue Reading

Citations

Nov 21, 2019·Drug Delivery·Yuzhu SunShuyu Xie
Dec 10, 2020·International Journal of Nanomedicine·Ze-Liang WuRong Xu

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