PMID: 26813276Jan 28, 2016Paper

Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis

Zhonghua yi xue za zhi
Changcai WuXiaojuan Zheng

Abstract

To compare the difference between the different perfusional regions in solid thyroid nodules. From October 2013 to May 2015, CEUS was performed in 59 patients who hospitalizated in Zhoushan Hospital with solid thyroid nodules before operation. The time-intensity curve (TIC) of normal thyroid tissue, tumor edge and tumor center was drawn to collect perfusion index like the peak intensity (PI), time to peak (TP), area under the curve (AUC), mean transit time (MTT). After surgery, immunohistochemical staining was performed to evaluate the MVD in surgical specimens.Quantitative parameters and MVD were assessed by the Spearman correlation analysis. There were 31 thyroid papillary carcinomas and 28 nodular goiters. In malignant tumor group, the PI of normal thyroid tissue, tumor edge and tumor center were 28% ± 6%, 21% ± 7% and 14% ± 5%, respectively, while the AUC and MVD of the same regions were (1 865 ± 1 079)%S, (1 376 ± 595)%S, (805 ± 412)%S and(33 ± 6), (27 ± 6)/HP, (17 ± 6)/HP, respectively. The differences were statistically significant. However, in benign tumor group, there was no obvious statistic difference in the quantitative parameters and MVD between the three regions. The PI values of thyroid carcinomas and nodular goi...Continue Reading

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