Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation

Colloids and Surfaces. B, Biointerfaces
Lisa RahnfeldPaola Luciani

Abstract

Compared to conventional parenteral formulations injectable depot formulations, owing to a sustained drug release, offer several advantages, such as a reduced dosing frequency - and consequent improved compliance - or a predictable release profile. Additionally, fluctuations in the drug blood level may be smoothened and consequently side effects reduced. Because of their capability to encapsulate water soluble drugs and their very low toxicity profile liposomes comprising phospholipids, most certainly represent a vehicle of choice for subcutaneous (s.c.) or intramuscular (i.m.) administration typical for depot injections too. In the past, especially liposomes containing negatively charged phosphatidylserines were investigated regarding their aggregation and fusion behavior upon addition of calcium ions. Liposomes need to have a large size to prevent fast removal from the s.c. or i.m. injection site to make them useful as depot vehicle. In order to obtain such large liposomes, aggregation of smaller liposomes may be considered. Aim of the present study was to induce and investigate controlled aggregation of vesicles containing other negatively charged phospholipids besides phosphatidylserines upon mixing with a solution of dival...Continue Reading

Citations

Aug 15, 2019·Microorganisms·Erica StewartNikolai Petrovsky
Jan 18, 2020·Nanoscale Research Letters·Yumiao HeChao Ma
Jun 25, 2020·Pharmaceutics·Lisa Rahnfeld, Paola Luciani
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maximilian RegenoldChristine Allen
Oct 5, 2020·Journal of Pharmaceutical and Biomedical Analysis·Yuchen FanKelly Zhang
Jun 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adam J S McCartanRandall J Mrsny

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