PMID: 15222264Jun 30, 2004Paper

Study on the levels of C-reactive protein and fibrinolytic activity in patients with obstructive sleep apnea syndrome

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Ying WangMingmin Dong

Abstract

To study the changes of plasm CRP levels and the fibrinolytic activity in patients with obstructive sleep apnea syndrome (OSAS). Thirty-two patients with OSAS, who were free of other diseases and had never been treated for OSAS, were as test group, 30 adults without OSAS were as control group. Plasma high-sensitivity CRP (hsCRP) levels and tissue-type plasminogen activator (t-PA) activity, plasminogen activator inhibitor-1 (PAI-1) activity were measured in two groups. In OSAS group the levels of CRP and the activity of PAI-1 were increased, the activity of t-PA were decreased as compared with control group (P < 0.01). The OSAS patients are associated with elevated plasma CRP level and decreased fibrinolytic activity. The severity of OSAS is proportional to the CRP level.

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