Study on the mechanism of HIF1a-SOX9 in glucose-induced cardiomyocyte hypertrophy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qianqian GaoXu Ma

Abstract

A major cause of morbidity and mortality in cardiovascular disease is pathological cardiac hypertrophy. With an increase in the cellular surface area and upregulation of the atrial natriuretic peptide (ANP) gene, cardiac hypertrophy is a prominent feature of diabetic cardiomyopathy. ANP is a hypertrophic marker. Many works have been done to explore how the glucose induces the cardiac hypertrophy. However, it is not enough for us to figure it out. In this study, the influences of different glucose concentrations on cardiomyocytes were examined in vitro. The results showed that cardiomyocytes cultured with 25mM glucose tended to show a hypertrophic phenotype, while cardiomyocytes cultured with 35mM glucose tended to undergo apoptosis. An increased expression of SOX9 was observed when cardiomyocytes were cultured with 25mM glucose, but when the concentration of glucose was increased to 35mM, the expression of SOX9 decreased. We used the RNAi approach to knockdown SOX9 expression, to assess its effects on cardiomyocyte hypertrophy. The results showed that knockdown of the SOX9 gene suppressed the 25mM glucose-induced cardiomyocyte hypertrophy. The upregulation of the ANP gene was associated with overexpression of SOX9. Additionally...Continue Reading

References

Jan 30, 2002·Cardiology in the Young·H S MenezesP Zielinsky
Oct 1, 2004·The Journal of Biological Chemistry·Ikuyo Kou, Shiro Ikegawa
Mar 2, 2006·The Journal of Pathology·A OrlandiG Gabbiani
Mar 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Daniela DyntarMarc Y Donath
Mar 18, 2006·Circulation Research·Indu G PoornimaRichard P Shannon
Nov 18, 2008·The International Journal of Biochemistry & Cell Biology·Guoling RenJun Lu
Jul 17, 2010·Journal of Applied Physiology·Romana BohuslavováGabriela Pavlinkova
Feb 15, 2012·Virchows Archiv : an International Journal of Pathology·Minhua SunMasashi Fukayama
Apr 30, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dongmei SuXu Ma

❮ Previous
Next ❯

Citations

Mar 14, 2019·Physiological Reviews·Sonsoles Piera-Velazquez, Sergio A Jimenez
Jan 7, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xuehan WuYisong Qian
Nov 30, 2018·Molecular Medicine Reports·Qian WangYan Meng
May 17, 2019·Oxidative Medicine and Cellular Longevity·Jinjun PuJiang Hong
Sep 30, 2016·Biochemical and Biophysical Research Communications·Dongmei SuXu Ma
Aug 23, 2021·Biochemical and Biophysical Research Communications·Yangyang Hu, Zhe Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis