Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain-intestine interaction in the treatment of insomnia.

Medicine
Ye ZhangHongshi Zhang

Abstract

Insomnia is a common disease associated with different nervous system stress response and endocrine disorders. It has been reported previously that abdominal vibration and ring massage therapy can significantly improve the symptoms of insomnia patients, enhance the activity of neurons. In addition, functional MRI (resting state brain functional magnetic resonance imaging [Rs_fMRI]) of the resting state brain test has proved that the functional connection between hypothalamus and parahippocampal gyrus could be significantly enhanced after abdominal massage treatment. It has been confirmed that there is possible involvement of brain-gut interaction effect in the treatment of insomnia, but there is a lack of research to elucidate the possible mechanisms of brain-gut interaction in the treatment of insomnia. The purpose of this study is to investigate the relationship between the hypothalamus and intestinal interaction in the treatment of insomnia by abdominal massage. A single blind randomized controlled trial will be conducted. Sixty chronic insomnia volunteers and 30 healthy volunteers will be recruited for this study. Sixty insomnia volunteers will be randomly divided into a drug group and a massage group, and 30 healthy volunt...Continue Reading

References

May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Sang H RheeEmeran A Mayer
Jun 18, 2015·Arquivos de neuro-psiquiatria·Carolina D'AureaMarco Tulio de Mello
Oct 9, 2015·The New England Journal of Medicine·John W Winkelman
Jan 1, 2015·Nature Reviews. Disease Primers·Charles M MorinKai Spiegelhalder
Oct 23, 2019·Journal of Sleep Research·Finja GerlachKeisuke Takano

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Methods Mentioned

BETA
ELISA
enzyme linked immunosorbent assay
NMR

Software Mentioned

DPARSF
SIMCA
SPM12
Xjview
Spss23
Realign
MestReNova

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