Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Huiping ChenYongcheng Lin

Abstract

The polar extract of the Dendrobium species or F. fimbriata (a substitute of Dendrobium), between the fat-soluble extract and polysaccharide has barely been researched. This report worked on the qualitative and quantitative studies of polar extracts from D. nobile, D. officinale, D. loddigesii, and F. fimbriata. Eight water-soluble metabolites containing a new diglucoside, flifimdioside A (1), and a rare imidazolium-type alkaloid, anosmine (4), were identified using chromatography as well as spectroscopic techniques. Their contents in the four herbs were high, approximately 0.9⁻3.7 mg/g based on the analysis of quantitative nuclear magnetic resonance (qNMR) spectroscopy. Biological activity evaluation showed that the polar extract of F. fimbriata or its pure component had good antioxidant and neuroprotective activity; compounds 1‒4 and shihunine (8) showed weak α-glucosidase inhibitory activity; 4 and 8 had weak anti-inflammatory activity. Under trial conditions, all samples had no cytotoxic activity.

References

Feb 1, 1968·Tetrahedron Letters·K Leander, B Lüning
Sep 1, 1994·Journal of Natural Products·C C ChenC M Teng
Sep 21, 2010·Fitoterapia·Mohammad Musharof Hossain
Apr 3, 2012·Chemical & Pharmaceutical Bulletin·Hari Prasad DevkotaShoji Yahara
Feb 25, 2014·Journal of Agricultural and Food Chemistry·Oliver FrankThomas Hofmann
Jun 25, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu LuYong-Cheng Lin
May 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yau LamKalin Yanbo Zhang
Jul 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yinnan SunShouxin Liu

❮ Previous
Next ❯

Citations

Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xue-Wen LiJun Wang
May 8, 2021·Frontiers in Pharmacology·Zongmin MouDake Zhao
Jul 2, 2021·International Journal of Biological Macromolecules·Wen-Hua ChenLu-Ping Qin

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
circular dichroism

Software Mentioned

qNMR
Topspin
ERETIC2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Xiao-Mei Chen, Shun-Xing Guo
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Mei-Qiu YanXia Liu
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Yan ZhuJingping Si
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Hua ZhuTao Wei
© 2022 Meta ULC. All rights reserved