PMID: 16635319Apr 26, 2006Paper

Study on the relationship between copper, lysyl oxidase and premature rupture of membranes

Zhonghua fu chan ke za zhi
Hui-dan ZhangLian-feng Shan

Abstract

To determine the relationships between maternal serum copper, amniotic copper, lysyl oxidase (LOX) and collagen III in pregnant women with premature rupture of membranes (PROM) and without PROM. One hundred women with PROM were enrolled in this study, and divided into 37-42 weeks, 34-36(+6) weeks and 28-33(+6) weeks according to gestational age. One hundred non-PROM pregnancies matching the same gestational ages were recruited as control group. Copper of maternal serum and amnion in two groups were compared by FAAS method. Amniotic LOX was analyzed by fluorometry. Amniotic collagen III was detected by immunohistochemical method and computer image analysis system (absorbance, A). Linear correlation analysis was used to explore the relationships between maternal serum copper, amniotic copper, LOX and collagen III. (1) For 37-42 weeks pregnant women, serum copper was correlated positively with amniotic copper in two groups, r = 0.82 (P < 0.001), but for other parameters, the serum and amniotic levels had no correlations. (2) For 34-36(+6) and 28 - 33(+6) weeks pregnant women, there were positive correlations between serum copper, amniotic copper, LOX and collagen III in two groups (P < 0.01). (3) For 37-42 weeks pregnant women, se...Continue Reading

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