Study protocol evaluating the use of bowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter randomized controlled trial

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
R GarfinkleM Boutros

Abstract

Postoperative ileus is the most commonly observed morbidity following ileostomy closure. Studies have demonstrated that the defunctionalized bowel of a loop ileostomy undergoes a series of functional and structural changes, such as atrophy of the intestinal villi and muscular layers, which may contribute to ileus. A single-centre study in Spain demonstrated that preoperative bowel stimulation via the distal limb of the loop ileostomy decreased postoperative ileus, length of stay and time to gastrointestinal function. A multicentre randomized controlled trial involving patients from Canadian institutions was designed to evaluate the effect of preoperative bowel stimulation before ileostomy closure on postoperative ileus. Stimulation will include canalizing the distal limb of the ileostomy loop with an 18Fr Foley catheter and infusing it with a solution of 500 ml of normal saline mixed with 30 g of a thickening agent (Nestle© Thicken-Up© ). This will be performed 10 times over the 3 weeks before ileostomy closure in an outpatient clinic setting by a trained Enterostomal Therapy nurse. Surgeons and the treating surgical team will be blinded to their patient's group allocation. Data regarding patient demographics, and operative and...Continue Reading

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Citations

Jul 18, 2019·The British Journal of Surgery·R GarfinkleM Boutros
Jan 5, 2019·Langenbeck's Archives of Surgery·Fabian GrassMartin Hübner
Apr 10, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T RombeyN S Fearnhead
Apr 13, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A-K Eichelmann, A Pascher
Mar 7, 2021·Nutrients·Ángela Rodríguez-PadillaCarlos Ruiz-Frutos
May 1, 2021·Biology·Ángela Rodríguez-PadillaCarlos Ruiz-Frutos
Jun 3, 2021·Biomolecules·Ángela Rodríguez-PadillaCarlos Ruiz-Frutos
Jul 13, 2021·Frontiers in Medicine·Ángela Rodríguez-PadillaCarlos Ruiz-Frutos

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