Study protocol: evaluation of the probiotic Lactobacillus Fermentum CECT5716 for the prevention of mastitis in breastfeeding women: a randomised controlled trial

BMC Pregnancy and Childbirth
Diana M BondNatasha Nassar

Abstract

Mastitis and accompanying pain have been associated with the cessation of breastfeeding. Mastitis is an inflammatory condition of the breast and may be a result of decreased immunity and a lowered resistance to infection. Mastitis affects up to one in five breastfeeding women with most episodes occurring in the first 6-8 weeks postpartum. Antibiotics are often used in the treatment of mastitis, but have not been popular or proven effective as a preventative agent. The WHO has highlighted significant concerns relating to adverse harms of antibiotic use with the production of antibiotic-resistant strains of disease organisms. Increasing research suggests that specific probiotic bacteria possess significant anti-inflammatory properties and supports their potential use as immunomodulatory agents. While animal studies have shown promising results in the use of probiotics for preventing mastitis, their use in human trials has had limited investigation. The aim of this study is to evaluate the effectiveness of oral probiotics for the prevention of mastitis in breastfeeding women. APProve (CAn Probiotics ImProve Breastfeeding Outcomes?) is a double-blind randomised controlled trial designed to assess outcomes between breastfeeding wome...Continue Reading

References

Sep 1, 1992·The British Journal of Clinical Psychology·T M Marteau, H Bekker
Jan 1, 1991·Social Science & Medicine·R Kaufmann, B Foxman
Jun 1, 1990·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·J M Riordan, F H Nichols
Mar 21, 1998·British Journal of Obstetrics and Gynaecology·S Brown, J Lumley
Oct 17, 1998·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·C Fetherston
Jun 4, 1999·Current Microbiology·V S OcañaM E Nader-Macías
Dec 1, 1999·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·V Livingstone, L J Stringer
Feb 3, 2000·Birth·A VogelE A Mitchell
Feb 7, 2001·The American Journal of Clinical Nutrition·E IsolauriS Salminen
Jan 16, 2002·American Journal of Epidemiology·Betsy FoxmanKendra Schwartz
Mar 5, 2003·World Journal of Surgery·Cenap Dener, Aydin Inan
Aug 13, 2003·Journal of Applied Microbiology·M P Heikkilä, P E J Saris
Dec 6, 2003·The Journal of Pediatrics·Rocío MartínJuan M Rodríguez
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Lisa H AmirJudith Lumley
Feb 1, 2005·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Rocío MartínJuan M Rodríguez
Aug 18, 2005·New South Wales Public Health Bulletin·Jane Allen, Debra Hector
Sep 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y M SjögrenM C Jenmalm
May 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rebeca ArroyoJuan Miguel Rodríguez
Feb 15, 2011·BMJ : British Medical Journal·J Michael Dixon, Lucy R Khan
May 6, 2011·The American Journal of Clinical Nutrition·Yolanda Sanz
Nov 15, 2011·The Journal of Dairy Research·Ignacio D FrolaCristina I Bogni
Dec 18, 2012·Expert Review of Anti-infective Therapy·Rafael Cantón, Jenny Bryan
Oct 9, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·J CleminsonW McGuire
Nov 28, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leónides FernándezJuan Miguel Rodríguez
Feb 13, 2016·Lancet·Cesar G VictoraUNKNOWN Lancet Breastfeeding Series Group

❮ Previous
Next ❯

Citations

Apr 15, 2020·Nutrients·Katríona E LyonsCatherine Stanton
Sep 29, 2020·The Cochrane Database of Systematic Reviews·Maree A CrepinsekFiona Stewart
May 24, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Shi WanchaoShi Mengmeng
Apr 6, 2019·Scientific Reports·Stephania Aragón-RojasFabian Leonardo Moreno
Jul 23, 2018·Applied Microbiology and Biotechnology·Zhongwang ZhangYongguang Zhang
Feb 6, 2020·Journal of Dairy Science·Ignasi Azagra-BoronatM José Rodríguez-Lagunas
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Vittorio SaettoneGiorgia Meineri
Feb 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jose Alberto Molina-TijerasJulio Gálvez
Mar 9, 2020·Women and Birth : Journal of the Australian College of Midwives·Melissa BarkerMary Steen
Apr 1, 2021·Tropical Animal Health and Production·Amr El-Sayed, Mohamed Kamel

❮ Previous
Next ❯

Software Mentioned

SPSS
Lite
Survey Monkey
APProve

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.