Study protocol for prognosis and treatment strategy of peripheral persistent avascular retina after intravitreal anti-VEGF therapy in retinopathy of prematurity.

Trials
Ying YuDaoman Xiang

Abstract

Prophylactic peripheral photocoagulation has been proposed to be applied to persistent, peripheral, avascular retina for retinopathy of prematurity (ROP) patients who have received an intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents. However, there are doubts regarding the necessity of this prophylactic action regardless of fundus fluorescein angiography (FFA) results. The adverse prognosis for persistent avascular retina after anti-VEGF therapy in ROP patients is not well understood. The relationship between vascular leakage and an adverse prognosis is also unknown. Therefore, it would be of value to study the above issues to shape the treatment strategy of persistent avascular retina after intravitreal anti-VEGF therapy in ROP patients. This is a prospective study of ROP patients with persistent avascular retina who have received anti-VEGF intravitreal therapy and have never received laser therapy. All the eyes being studied will be followed up and examined by FFA after anti-VEGF treatment and categorized into two groups, a leakage group and a non-leakage group according to the extent of vascular leakage from FFA results. The eyes being studied in the leakage group will be further randomize...Continue Reading

References

Dec 1, 1987·Pediatric Clinics of North America·J T Flynn
Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
Jan 30, 2008·American Journal of Ophthalmology·Richard S KaiserMichael T Trese
Feb 18, 2011·The New England Journal of Medicine·Helen A Mintz-HittnerUNKNOWN BEAT-ROP Cooperative Group
Apr 12, 2012·Archives of Ophthalmology·Jennifer HuRashmi Kapur
Jul 18, 2012·Archives of Ophthalmology·Ravi D PatelSteven J Lichtenstein
Apr 24, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Shaun IttiaraSteven J Lichtenstein
Apr 5, 2014·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Andree Henaine-BerraMaria Ana Martinez-Castellanos
Oct 23, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Alistair FielderClare Gilbert
Mar 18, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Laura L SnyderMichael P Blair
Dec 26, 2016·Survey of Ophthalmology·Mary Elizabeth Hartnett
Dec 11, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Kathleen A KennedyUNKNOWN BEAT-ROP Cooperative Group
Sep 21, 2018·Biomedical Engineering Online·Zhe JiangYanye Lu

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