Study protocol for the Australian autism biobank: an international resource to advance autism discovery research

BMC Pediatrics
Gail A AlvaresAustralian Autism Biobank team

Abstract

The phenotypic and genetic heterogeneity of autism spectrum disorder (ASD) presents considerable challenges in understanding etiological pathways, selecting effective therapies, providing genetic counselling, and predicting clinical outcomes. With advances in genetic and biological research alongside rapid-pace technological innovations, there is an increasing imperative to access large, representative, and diverse cohorts to advance knowledge of ASD. To date, there has not been any single collective effort towards a similar resource in Australia, which has its own unique ethnic and cultural diversity. The Australian Autism Biobank was initiated by the Cooperative Research Centre for Living with Autism (Autism CRC) to establish a large-scale repository of biological samples and detailed clinical information about children diagnosed with ASD to facilitate future discovery research. The primary group of participants were children with a confirmed diagnosis of ASD, aged between 2 and 17 years, recruited through four sites in Australia. No exclusion criteria regarding language level, cognitive ability, or comorbid conditions were applied to ensure a representative cohort was recruited. Both biological parents and siblings were invi...Continue Reading

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Citations

Nov 10, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gail A AlvaresAndrew J O Whitehouse
Feb 12, 2021·Molecular Autism·Chloe X YapJacob Gratten
Nov 6, 2021·Journal of Autism and Developmental Disorders·Jess E ReynoldsMelissa K Licari

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Methods Mentioned

BETA
blood collection
urine collection

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