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Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1 -mutated or IDH2 -mutated solid tumours

BMJ Open

Jun 12, 2017

Remco J MolenaarJohanna W Wilmink

Abstract

High-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to the lack of effective treatment options, emphasising the need for novel therapies. Mutations in the genes IDH1 and IDH2 (isocitrate dehyd...read more

Mentioned in this Paper

Chondrosarcoma
Study
Urine
Metformin
Antineoplastic Agents
Scientific Study
Chondrosarcoma of Bone
Academic Medical Centers
Clinical Trial, Phase II
Tumor Tissue Sample
2
45
Paper Details
References
  • References64
  • Citations7
12345...
  • References64
  • Citations7
1

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Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1 -mutated or IDH2 -mutated solid tumours

BMJ Open

Jun 12, 2017

Remco J MolenaarJohanna W Wilmink

PMID: 28601826

DOI: 10.1136/bmjopen-2016-014961

Abstract

High-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to the lack of effective treatment options, emphasising the need for novel therapies. Mutations in the genes IDH1 and IDH2 (isocitrate dehyd...read more

Mentioned in this Paper

Chondrosarcoma
Study
Urine
Metformin
Antineoplastic Agents
Scientific Study
Chondrosarcoma of Bone
Academic Medical Centers
Clinical Trial, Phase II
Tumor Tissue Sample
2
45

Similar Papers Found In These Feeds

Type 2 Diabetes

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

Chondrosarcoma

Chondrosarcoma is a type of cancer that involves cartilage cells. Here is the latest research on chonndrosarcomas.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchJanuary 31, 2014
Darrell R BorgerAndrew X Zhu
British Journal of Cancer

Sunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study

British Journal of CancerMarch 21, 2013
M D MichaelsonA B Schwarzberg
Paper Details
References
  • References64
  • Citations7
12345...
  • References64
  • Citations7
1
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