Study protocol of the DUtch PARkinson Cohort (DUPARC): a prospective, observational study of de novo Parkinson's disease patients for the identification and validation of biomarkers for Parkinson's disease subtypes, progression and pathophysiology

BMC Neurology
Jeffrey M BoertienPPNN Study Group

Abstract

Parkinson's Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. Here, the study protocol of the Dutch Parkinson Cohort (DUPARC) is described. DUPARC is a longitudinal cohort study aimed at deeply phenotyping de novo PD patients who are treatment-naïve at baseline, to discover and validate biomarkers for PD progression, subtypes and pathophysiology. DUPARC is a prospective cohort study in which 150 de novo PD subjects will be recruited through a collaborative network of PD treating neurologists in the northern part of the Netherlands (Parkinson Platform Northern Netherlands, PPNN). Participants will receive follow-up assessments after 1 year and 3 years, with the intention of an extended follow-up with 3 year intervals. Subjects are extensively characterized to primarily assess objectives within three major domains of PD: cognition, gastrointestinal function and vision. This includes brain magnetic resonance imaging (MRI); brain cholinergic PET-imaging with fluoroethoxybenzovesamicol (FEOBV-PET); brain dopaminergic PET-imaging with fluorodopa (FDOPA-PET); detailed neuropsychological asse...Continue Reading

Associated Clinical Trials

Nov 29, 2019·Teus van Laar

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jun 21, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sonja von CampenhausenRichard Dodel
Apr 2, 2009·Brain : a Journal of Neurology·Neil K ArchibaldDavid J Burn
Feb 16, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Stephanie M van RoodenJacobus J van Hilten
May 9, 2012·Investigative Ophthalmology & Visual Science·Stuart J McKinnon
May 10, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicolaas I BohnenKirk A Frey
Oct 4, 2012·BMC Ophthalmology·Evangelia E TsironiGeorgios M Hadjigeorgiou
Aug 15, 2013·Current Neurology and Neuroscience Reports·Martijn L T M Müller, Nicolaas I Bohnen
Jan 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Naomi P VisanjiAnthony E Lang
Feb 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Myria PetrouRobert A Koeppe
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanJames E Galvin
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Glenda M HallidayCharles H Adler
Jun 14, 2014·Journal of Epidemiology and Community Health·Chirag J Patel, John P A Ioannidis
Jul 31, 2014·Parkinsonism & Related Disorders·Rachael A LawsonDavid J Burn
Dec 17, 2014·International Journal of Epidemiology·Salome ScholtensRonald P Stolk
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Mar 27, 2016·Annals of Neurology·Morten Gersel StokholmPer Borghammer
Jul 15, 2016·Brain : a Journal of Neurology·Rimona S WeilHuw R Morris
Nov 3, 2016·Current Opinion in Neurology·Rainer von Coelln, Lisa M Shulman
Mar 13, 2017·Parkinsonism & Related Disorders·Merel S EkkerBastiaan R Bloem
Mar 23, 2017·Reviews in the Neurosciences·Hossein Sanjari MoghaddamNima Rezaei
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Li GuoM Francesca Cordeiro
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·David P BreenAnthony E Lang
Feb 6, 2019·Annals of Neurology·Nicolaas I BohnenMartijn L T M Müller
Apr 13, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sygrid van der ZeeTeus van Laar
May 6, 2019·Parkinsonism & Related Disorders·Asterios ChrysouTeus van Laar
Sep 10, 2019·Journal of Parkinson's Disease·Jeffrey M BoertienFilip Scheperjans
Sep 29, 2019·Journal of Parkinson's Disease·Sven C D van IJzendoorn, Pascal Derkinderen

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Citations

Jan 18, 2022·Movement Disorders : Official Journal of the Movement Disorder Society·Sygrid van der ZeeTeus van Laar

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Methods Mentioned

BETA
chip

Clinical Trials Mentioned

NCT04180865

Software Mentioned

LifeLines
DUPARC

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