Study to Probe Subsistence of Host-Guest Inclusion Complexes of α and β-Cyclodextrins with Biologically Potent Drugs for Safety Regulatory Dischargement

Scientific Reports
Biplab RajbanshiMahendra Nath Roy

Abstract

Host-guest interaction of two significant drugs, phenylephrine hydrochloride and synephrine with α and β-cyclodextrins were studied systematically. Initially two simple but reliable physicochemical techniques namely conductance and surface tension were employed to find out saturation concentration for the inclusion and its stoichiometry. The obtained 1:1 stoichiometry was further confirmed by two spectrometric methods, UV-Vis study and spectrofluorimetry. Significant shifts in IR stretching frequency also support the inclusion process. Relative stabilities of the inclusion complexes were established by the association constants obtained from UV-Vis spectroscopic measurements, program based mathematical calculation of conductivity data. Calculations of the thermodynamic parameters dictates thermodynamic feasibility of the inclusion process. Spectrofluorometric measurement scaffolds the UV-Vis spectroscopic measurement validating stability of the ICs once again. Mass spectroscopic measurement gives the molecular ion peaks corresponding to the inclusion complex of 1:1 molar ratio of host and guest molecules. The mechanism of inclusion was drawn by 1H-NMR and 2D ROESY spectroscopic analysis. Surface texture of the inclusion complex...Continue Reading

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Citations

Feb 13, 2021·Drug Development and Industrial Pharmacy·Bhupendra Raj GiriDong Wuk Kim
Jul 3, 2021·Environmental Science and Pollution Research International·Kazım KöseLokman Uzun
Dec 3, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·J Queiros CamposP Kuzhir

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Methods Mentioned

BETA
electrophoresis
Fluorescence
NMR
Scanning Electron Microscopy

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