Studying cancer metastasis: Existing models, challenges and future perspectives

Critical Reviews in Oncology/hematology
Denise M S van MarionAnnemiek M E Walenkamp

Abstract

Cancer metastasis causes most cancer-related deaths. Several model systems to study the complex and multi step process of metastasis exist, including in vitro systems, ex-vivo organ slices, Drosophila Melanogaster and zebrafish models and the use of the chorio allantoic membrane (CAM) of fertilized chicken eggs. These models are relatively easy and cheap but often lack the opportunity to study the complete metastasis cascade. More complex but also more expensive is the use of animal models including the more recently developed patient derived tumor xenografts (PDTX). In this review, we give an overview of the existing metastatic models, discuss the challenges of improving current models to enhance translation from the preclinical to the clinical setting and consider future perspectives.

References

Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·I G MaroulakouJ E Green
Mar 22, 1996·Science·D R LeachJ P Allison
Sep 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A M EngelO Werdelin
Jun 9, 1998·Stem Cells·D L GreinerL D Shultz
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M JeffersG F Vande Woude
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
May 2, 2002·Nature Genetics·Kam D DahlquistBruce R Conklin
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Sep 21, 2002·Journal of Cancer Research and Clinical Oncology·Shin JungKyu-Youn Ahn
Feb 8, 2003·Science·David M LangenauA Thomas Look
Oct 1, 2003·Angiogenesis·P D Brown
Dec 6, 2003·Cell Cycle·Elisa C Woodhouse, Lance A Liotta
Jan 2, 2004·Breast Cancer Research and Treatment·George N NaumovAnn F Chambers
Aug 3, 2004·Science·Douglas R Green, Guido Kroemer
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John RinehartMark B Meyer
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Belen Rubio-ViqueiraManuel Hidalgo
Jan 24, 2007·Developmental Biology·Michelle BeaucherAllen Shearn
Jan 30, 2007·Nature Reviews. Immunology·Leonard D ShultzDale L Greiner
Sep 4, 2007·The Oncologist·Rudolf S N FehrmannAnne P G Crijns
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter J CampbellMichael R Stratton
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Sep 10, 2008·Angiogenesis·Anca Maria CimpeanMarius Raica
Nov 14, 2008·Histochemistry and Cell Biology·Elena I Deryugina, James P Quigley
Nov 29, 2008·Science·Charles G MullighanJames R Downing
Mar 27, 2009·Physical Biology·Ignacio Ramis-CondeDirk Drasdo
Jan 26, 2010·The Journal of Pathology·Felipe C GeyerJorge S Reis-Filho
Mar 23, 2010·Biochemical Pharmacology·Maria RussoGian Luigi Russo
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber

❮ Previous
Next ❯

Citations

Feb 7, 2016·Cancer Letters·Bo Young OhYong Beom Cho
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Stephan PhilippDieter Adam
Jul 29, 2016·Journal of Agricultural and Food Chemistry·Min GuoZhuoyu Li
Mar 10, 2017·Expert Opinion on Drug Discovery·Hannah K BrownTimothy Ja Chico
Dec 21, 2017·Frontiers in Pharmacology·Natalia V SegattoTiago Collares
May 8, 2020·Expert Opinion on Drug Discovery·Noah RobertsonKyle M Schachtschneider
Jun 9, 2018·Bioengineering·Claudia KühlbachMargareta M Mueller
Nov 24, 2016·Journal of Translational Medicine·Thais BascuasJosé A Chabalgoity
Mar 28, 2018·Oncotarget·Zhuoyu Li, Min Guo
Jan 5, 2019·F1000Research·David HillBill Chaudhry
Jan 5, 2021·Cancer Chemotherapy and Pharmacology·Haneen AmawiAmit K Tiwari
Jan 14, 2021·Biomaterials Science·Kanishka FernandoEliza Li Shan Fong
Aug 30, 2019·Cell Systems·Yasir Suhail Kshitiz
Sep 9, 2019·ACS Biomaterials Science & Engineering·Hilaria MollicaPaolo Decuzzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adenosarcoma

Adenosarcoma is a rare tumor found in women and is located in the uterus, but can also arise in the cervix and ovaries. Discover the latest research on Adenosarcoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.