Studying chromosome instability in the mouse.

Biochimica Et Biophysica Acta
Floris FoijerPeter K Sorger

Abstract

Aneuploidy has long been recognized as one of the hallmarks of cancer. It nonetheless remains uncertain whether aneuploidy occurring early in the development of a cancer is a primary cause of oncogenic transformation, or whether it is an epiphenomenon that arises from a general breakdown in cell cycle control late in tumorigenesis. The accuracy of chromosome segregation is ensured both by the intrinsic mechanics of mitosis and by an error-checking spindle assembly checkpoint. Many cancers show altered expression of proteins involved in the spindle checkpoint or in proteins implicated in other mitotic processes. To understand the role of aneuploidy in the initiation and progression of cancer, a number of spindle checkpoint genes have been disrupted in mice, most through conventional gene targeting (to create germ-line knockouts). We describe the consequence of these mutations with respect to embryonic development, tumor progression and an unexpected link to premature aging; readers are referred elsewhere [1] for a discussion of other cell cycle regulators.

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Citations

Dec 31, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sarah L Thompson, Duane A Compton
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Aniek JanssenRené H Medema
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Floris FoijerAllan Bradley
Feb 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabrizio GalimbertiEthan Dmitrovsky
Nov 2, 2012·The Journal of Clinical Investigation·Michael S HuhDavid J Picketts
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Feb 4, 2010·The Journal of Cell Biology·Sarah L Thompson, Duane A Compton
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Sep 23, 2008·Biochimica Et Biophysica Acta·René H Medema
May 23, 2012·EMBO Reports·Sarah J Pfau, Angelika Amon
Jun 3, 2010·Journal of Cellular Biochemistry·Phillip Kaestner, Holger Bastians
May 9, 2012·EMBO Reports·Andrew J Holland, Don W Cleveland
May 28, 2015·Cell Division·Maybelline Giam, Giulia Rancati
Mar 6, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bjorn BakkerFloris Foijer
May 6, 2015·ELife·Joshua M NicholsonDaniela Cimini
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Floris FoijerPeter K Sorger
Jan 14, 2011·Cytogenetic and Genome Research·F Pacchierotti, U Eichenlaub-Ritter
Aug 18, 2016·Molecular Carcinogenesis·Chinthalapally V RaoHiroshi Y Yamada
Nov 14, 2016·Carcinogenesis·Chinthalapally V RaoHiroshi Y Yamada
Jun 30, 2016·World Journal of Stem Cells·Jorge Garcia-MartinezFloris Foijer
Dec 2, 2010·Biochemical Society Transactions·Floris Foijer
Jan 26, 2020·Life Science Alliance·Klaske M SchukkenFloris Foijer

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