Studying human and nonhuman primate evolutionary biology with powerful in vitro and in vivo functional genomics tools

Evolutionary Anthropology
Kathleen E Grogan, George H Perry

Abstract

In recent years, tools for functional genomic studies have become increasingly feasible for use by evolutionary anthropologists. In this review, we provide brief overviews of several exciting in vitro techniques that can be paired with "-omics" approaches (e.g., genomics, epigenomics, transcriptomics, proteomics, and metabolomics) for potentially powerful evolutionary insights. These in vitro techniques include ancestral protein resurrection, cell line experiments using primary, immortalized, and induced pluripotent stem cells, and CRISPR-Cas9 genetic manipulation. We also discuss how several of these methods can be used in vivo, for transgenic organism studies of human and nonhuman primate evolution. Throughout this review, we highlight example studies in which these approaches have already been used to inform our understanding of the evolutionary biology of modern and archaic humans and other primates while simultaneously identifying future opportunities for anthropologists to use this toolkit to help answer additional outstanding questions in evolutionary anthropology.

References

Feb 17, 2000·Trends in Ecology & Evolution·B S Chang, M J Donoghue
May 3, 2000·American Journal of Epidemiology·A Ashley-KochR S Olney
Nov 23, 2000·Nature·T B Kirkwood, S N Austad
Apr 17, 2002·Science·Howard M CannL Luca Cavalli-Sforza
Sep 5, 2002·Genes and Immunity·D J Weatherall, J B Clegg
Feb 15, 2003·Life Sciences·Thomas T SamarasLowell H Storms
Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ian A CockburnJ Alexandra Rowe
Apr 2, 2005·Nature Reviews. Genetics·L Luca Cavalli-Sforza
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
Sep 6, 2005·Science·Edwin H McConkey, Ajit Varki
Dec 13, 2005·Genome Research·Ajit Varki, Tasha K Altheide
Jun 23, 2006·PLoS Computational Biology·Paul D WilliamsRichard A Goldstein
Jul 27, 2007·Proceedings. Biological Sciences·Susanne Shultz, R I M Dunbar
Sep 8, 2007·Science·R I M Dunbar, Susanne Shultz
Oct 27, 2007·Science·Carles Lalueza-FoxMichael Hofreiter
Jan 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rushina CholeraRick M Fairhurst
Apr 25, 2008·Current Protocols in Immunology·Giovanna Tosato, Jeffrey I Cohen
Sep 6, 2008·Science·Shyam PrabhakarJames P Noonan
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R M MacKieA M M Eggermont
Nov 13, 2009·Nature·Genevieve KonopkaDaniel H Geschwind
Dec 3, 2009·Cell Stem Cell·Krishanu Saha, Rudolf Jaenisch
Dec 24, 2009·Nucleic Acids Research·Adrian W BriggsSvante Pääbo
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Franck PrugnolleFrançois Renaud
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ralph HaygoodGregory A Wray
May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nina G Jablonski, George Chaplin
May 8, 2010·Science·Richard E GreenSvante Pääbo
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M BeallYong Tang Zheng
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Angela M HancockAnna Di Rienzo
Aug 19, 2010·Nature Reviews. Genetics·Marilyn E CoorsJames M Sikela
Sep 16, 2010·Evolution; International Journal of Organic Evolution·Ian BarnesMark G Thomas
Oct 19, 2010·Genes & Development·Matthias Stadtfeld, Konrad Hochedlinger

❮ Previous
Next ❯

Citations

Jun 20, 2020·Bioanalysis·Sheila LópezLuciana Pizzatti
Apr 23, 2021·ELife·Carly V WeissDavid Gokhman
Jun 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Stephanie MarciniakGeorge H Perry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Evolutionary Anthropology
Jason M Kamilar
Annual Review of Microbiology
Austin BoothW Ford Doolittle
Evolutionary Anthropology
Mhairi A Gibson, David W Lawson
Journal of Physiological Anthropology
A Theodore Steegmann
© 2021 Meta ULC. All rights reserved