Studying the anti-tyrosinase effect of Arbutus andrachne L. extracts

International Journal of Cosmetic Science
R A IssaB I Amro

Abstract

Arbutus andrachne L. is widely distributed in Jordan. Tyrosinase is the key enzyme in the biosynthesis of melanin. This preliminary study was carried out to assess the possible anti-tyrosinase activity of A. andrachne extracts. Arbutin, hydroquinone and kojic acid were selected as inhibitor standards. Five different extracts (chloroform, butanol, ethanol, methanol and water) were prepared from A. andrachne stems and their activities were compared with the selected tyrosinase inhibitors. IC(50) was measured for both, standard and plant extracts. Among the different extracts, the methanolic extract exhibited the highest anttyrosinase activity with an IC(50) value (1 mg mL(-1)). Furthermore, 9 mg A. andrachne methanolic extract showed 97.49% inhibition of tyrosinase activity. Arbutin, hydroquinone, beta-sitosterol and ursolic acid were identified in the different extracts of A. andrachne by thin layer chromatography (TLC) and isolated by preparative TLC from the methanolic and chloroform stem extracts, respectively.

References

Sep 1, 1996·Chemical & Pharmaceutical Bulletin·K Morisaki, S Ozaki
Sep 24, 1998·Contact Dermatitis·E Serra-BaldrichJ G Camarasa
Nov 13, 2001·American Journal of Clinical Dermatology·A Pérez-BernalF Camacho
Nov 27, 2001·Journal of Natural Products·K Likhitwitayawuid, B Sritularak
Sep 21, 2002·Journal of Ethnopharmacology·N BaurinP Bernard
Mar 8, 2003·Pigment Cell Research·Stefania BrigantiMauro Picardo
May 2, 2003·Journal of Agricultural and Food Chemistry·Sung-Yum SeoNiti Sharma
Nov 5, 2003·Phytotherapy Research : PTR·Talal Aburjai, Feda M Natsheh
Dec 28, 2004·Journal of Dermatological Science·Vincent J Hearing
Jan 25, 2005·Bioscience, Biotechnology, and Biochemistry·Toshiya MasudaShigetomo Yonemori
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Bong-Jeun AnMyung-Woo Byun
Feb 25, 2006·Journal of Ethnopharmacology·Kuo-Hsien WangMei-Hsien Lee
Apr 25, 2007·Journal of Toxicology and Environmental Health. Part a·Jung-Hee Hwang, Byung Mu Lee
May 23, 2008·International Journal of Cosmetic Science·L Petit, G E Piérard

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Citations

Jan 8, 2010·International Journal of Molecular Sciences·Nico SmitStan Pavel
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Sep 16, 2017··Minh-Tam K. NguyenThao-My Nguyen

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