Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography.

Clinical EEG and Neuroscience
Recep AvciHari Eswaran

Abstract

Background. Developmental origin of health and disease states that an adverse intrauterine environment can lead to different diseases in later life. In this study, we aimed to explore the effect of maternal pregestational diabetes on the fetal brain activity using magnetoencephalography (MEG). Methods. Forty participants were included in an observational study with 9 type 1 and 19 type 2 diabetic pregnant women compared with data from 12 nondiabetic participants. Spontaneous fetal MEG signals were recorded and power spectral density was computed in 4 standard frequency bands. Group differences were investigated using analysis of covariance. Results. Our results showed that type 1 group was significantly different (P < .05) from the reference group for 3 of the 4 brain activity frequency bands, while in type 2 group, 2 bands exhibited this trend. When dichotomized based on the maternal glycemic control, significant differences in all bands were observed between the poor-control and reference groups. Conclusion. The fetal background brain activity parameters appear to be altered in diabetic pregnancy in comparison with the reference low-risk group. The study showed that maternal pregestational diabetes could potentially influence...Continue Reading

References

Nov 1, 1990·American Journal of Obstetrics and Gynecology·T RizzoP Barglow
Sep 21, 2000·Early Human Development·N N Doherty, P G Hepper
May 26, 2004·Pediatric Clinics of North America·Joan L Nold, Michael K Georgieff
Aug 20, 2005·Developmental Medicine and Child Neurology·Tracy DeBoerCharles A Nelson
Aug 19, 2006·IEEE Transactions on Bio-medical Engineering·J McCubbinH Eswaran
Jul 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hari EswaranCurtis L Lowery
Jun 6, 2008·American Journal of Obstetrics and Gynecology·Isabelle KieferHari Eswaran
Jul 26, 2008·Seminars in Perinatology·Curtis L LoweryHari Eswaran
Dec 5, 2008·The Journal of Pediatrics·N L Gonzalez-GonzalezJ L Bartha
Aug 28, 2009·Seminars in Reproductive Medicine·Pathik D WadhwaJames M Swanson
Feb 26, 2010·Developmental Neuropsychology·Ingrid M CordónCharles A Nelson
Aug 21, 2010·Endocrinology and Metabolism Clinics of North America·David M MaahsElizabeth J Mayer-Davis
Oct 11, 2011·Early Human Development·Hari EswaranCurtis L Lowery
Jul 23, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·José Ramón Castro CondeElena Sosa Comino
Oct 16, 2015·The Journal of Clinical Endocrinology and Metabolism·Katarzyna LinderAndreas Fritsche
Dec 15, 2015·Early Human Development·Noirin E RussellFionnuala M McAuliffe
Aug 12, 2016·The Medical Journal of Australia·Sally K AbellHelena J Teede
Dec 29, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·E FehlertA Fritsche
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Sep 1, 2021·Computational Intelligence and Neuroscience·Annamalai R, Nedunchelian R

❮ Previous
Next ❯

Software Mentioned

DataEditor
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Birth Defects Research. Part A, Clinical and Molecular Teratology
Niamh CorriganFionnuala M McAuliffe
Seminars in Perinatology
B A Meyer, S M Palmer
Current Diabetes Reviews
Mary Higgins, Fionnuala Mc Auliffe
Acta geneticae medicae et gemellologiae
T KonwinskiE Papiernik-Berkhauer
© 2021 Meta ULC. All rights reserved