PMID: 16515451Mar 7, 2006Paper

Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy

Protein and Peptide Letters
Guy LippensIsabelle Landrieu

Abstract

The neuronal Tau protein, whose physiological role is to stabilize the microtubules, is found under the form of aggregated filaments and tangles in Alzheimer's diseased neurons. Until recently detailed structural analysis of the natively unfolded Tau protein has been hindered due to its shear size and unfavourable amino acid composition. We review here the recent progress in the assignments of the full-length polypeptide using novel methods of product planes and peptide NMR mapping, and indicate the structural insights that can be obtained from this assignment. Preliminary NMR data on the fibers show that the assignment enables a precise mapping of the rigid core. Future NMR experiments should allow one to gain more insight into the conformational aspects of this intriguing protein.

Citations

May 10, 2008·Expert Review of Proteomics·Nicolas SergeantLuc Buée
Dec 14, 2007·Proteins·Swasti RaychaudhuriNitai P Bhattacharyya
Jun 24, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Caroline Smet-NoccaArndt Benecke
Sep 24, 2015·Acta Neuropathologica Communications·Yoann SottejeauJean-Charles Lambert
Feb 11, 2015·Cellular and Molecular Life Sciences : CMLS·Sarah N FontaineChad A Dickey
Mar 3, 2009·Biochemical and Biophysical Research Communications·Xavier HanoulleGuy Lippens
Jun 25, 2016·Biomolecules·Guy LippensJuan Lopez
Nov 6, 2018·Frontiers in Endocrinology·Gwendoline BourréCaroline Smet-Nocca
Jul 28, 2010·Biochemical Society Transactions·Isabelle LandrieuGuy Lippens
Jun 3, 2008·Biochemistry·Caroline Smet-NoccaArndt Benecke
Feb 15, 2007·Biochemistry·Daniela FischerMarkus Zweckstetter

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