Stumbling corrective reaction elicited by mechanical and electrical stimulation of the saphenous nerve in walking mice

The Journal of Experimental Biology
William P Mayer, Turgay Akay

Abstract

The ability to walk around in a natural environment requires the capacity to cope with unexpected obstacles that may disrupt locomotion. One such mechanism is called the stumbling corrective reaction (SCR) that enables animals to step over obstacles that would otherwise disturb the progression of swing movement. Here we use in vivo motion analysis and physiological recording techniques to describe the SCR in mice. We show that SCR can be elicited consistently in mice during locomotion by inserting an obstacle along the path of leg movement during swing phase. Furthermore, we show that the same behavior can be elicited if the saphenous nerve, a cutaneous nerve that would detect contact of the leg with an object, is stimulated electrically. This suggests that cutaneous afferent feedback is sufficient to elicit SCR. We further show that the SCR is phase dependent, occurring only with stimulation during swing phase, but not during early stance. During SCR elicited by either method, the foot is lifted higher to clear the object by flexing the knee, via the semitendinosus muscle, and ankle joint, by tibialis anterior contraction. The tibialis anterior also exhibits a brief extension before flexion onset. Our data provide a detailed d...Continue Reading

References

Feb 21, 1975·Brain Research·H ForssbergS Rossignol
Jan 1, 1990·Experimental Brain Research·J DuysensV Dietz
Jan 1, 1980·Experimental Brain Research·P WandK H Sontag
Jul 1, 1996·Journal of Neuroscience Methods·A M SchillingsJ Duysens
Mar 29, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Holk CruseJosef Schmitz
May 24, 2005·Journal of Neuroscience Methods·K G PearsonK Fouad
May 27, 2005·Journal of Neurophysiology·Jorge QuevedoDavid A McCrea
Oct 29, 2005·The Journal of Comparative Neurology·Francisco J AlvarezMartyn Goulding
Apr 28, 2006·Journal of Neurophysiology·Turgay AkayKeir G Pearson
Oct 16, 2007·Brain Research Reviews·David A McCrea, Ilya A Rybak
Jan 31, 2009·Nature Protocols·Katharina ZimmermannPeter W Reeh
Jun 23, 2009·Nature Reviews. Neuroscience·Martyn Goulding
Nov 10, 2009·Current Opinion in Neurobiology·Sten Grillner, Thomas M Jessell
Jun 21, 2011·Journal of Neurotrauma·Adele E DoperalskiDena R Howland
Nov 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Turgay AkayThomas M Jessell
Jan 31, 2015·Cell·Steeve BouraneMartyn Goulding
Oct 31, 2015·Science·Steeve BouraneMartyn Goulding
Nov 10, 2015·Nature Neuroscience·Seung-Hyun WooArdem Patapoutian
Nov 13, 2015·Journal of Neurophysiology·Zrinka PotocanacJacques Duysens
Mar 5, 2016·Nature Reviews. Neuroscience·Ole Kiehn

❮ Previous
Next ❯

Citations

Mar 28, 2019·The Journal of Physiology·Alessandro SantuzAdamantios Arampatzis
Sep 13, 2019·Physiological Reviews·Sten Grillner, Abdeljabbar El Manira
Dec 29, 2020·Journal of Neurophysiology·Sten Grillner
Jun 11, 2019·Current Opinion in Physiology·Kimberly J Dougherty, Ngoc T Ha
Aug 28, 2021·International Journal of Molecular Sciences·Maxime LemieuxFrédéric Bretzner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved