STW 5 is effective in dextran sulfate sodium-induced colitis in rats.

International Journal of Colorectal Disease
Walaa WadieM T Khayyal

Abstract

An herbal preparation, STW 5, used clinically in functional dyspepsia and irritable bowel syndrome, has been shown to possess properties that may render it useful in inflammatory bowel disease (IBD). The present work was conducted to study its effectiveness in a rat model of IBD. An experimental model reflecting ulcerative colitis in man was adopted, whereby colitis was induced in Wistar rats by feeding them 5 % dextran sulfate sodium (DSS) in drinking water for one week. STW 5 and sulfasalazine (as a reference standard) were administered orally daily for 1 week before colitis induction and continued during DSS feeding. The animals were then sacrificed, and the severity of colitis was evaluated macroscopically and microscopically. Colon samples were homogenized for determination of reduced glutathione, tumor necrosis factor-α, and cytokine-induced neutrophil chemoattractant-3 as well as myeloperoxidase, glutathione peroxidase, and superoxide dismutase. In addition, colon segments were suspended in an organ bath to test their reactivity towards carbachol, KCl, and trypsin. STW 5 and sulfasalazine were both effective in preventing the shortening of colon length and the increase in both colon mass index and total histology score a...Continue Reading

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Citations

Dec 15, 2015·Digestive Diseases and Sciences·Chang Ho LeeSuhn Hee Kim
Jan 23, 2013·Basic & Clinical Pharmacology & Toxicology·Ebenezer O FarombiEwomazino E Egbeme
Aug 19, 2014·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal
Jan 23, 2013·Pharmaceutical Biology·A DadkhahJ Ashrafihelan
Jul 16, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed T KhayyalMona A El-Ghazaly
Nov 16, 2013·Toxicologic Pathology·Jason DeVoss, Lauri Diehl
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Feb 9, 2018·Digestive Diseases·Hans-Dieter Allescher, Heba Abdel-Aziz
Oct 30, 2019·World Journal of Gastroenterology : WJG·Mohamed T KhayyalHeba Abdel-Aziz
Feb 9, 2018·Digestive Diseases·Fermin Mearin, Peter Malfertheiner
Jun 10, 2021·BMC Complementary Medicine and Therapies·Sarah S MohamedMohamed T Khayyal
Nov 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Nehal G GamalMohamed T Khayyal

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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